Protein Alignment PRPF19 and Prpf19

DIOPT Version :10

• Sequence 1: NP_055317.1
• Gene: PRPF19 / 27339
• HGNCID: 17896
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_001240772.1
• Gene: Prpf19 / 28000
• MGIID: 106247
• Length: 523
• Species: Mus musculus
• Alignment Length: 523
• Identity: 501/523 - (95%)
• Similarity: 503/523 - (96%)
• Gaps: 19/523 - (3%)

Human     1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKP 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKP 65

Human    66 PSATSIPAILKALQDEW-------------------DAVMLHSFTLRQQLQTTRQELSHALYQHD 111
            |||||||||||||||||                   |||||||||||||||||||||||||||||
Mouse    66 PSATSIPAILKALQDEWGWPNSPALPQSSQWPTLSQDAVMLHSFTLRQQLQTTRQELSHALYQHD 130

Human   112 AACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKL 176
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 AACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKL 195

Human   177 QDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGG 241
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 QDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGG 260

Human   242 ADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHE 306
            |||||||||||:|||||||||||||||||||||||:||||||||||||||||||.||||||||||
Mouse   261 ADKNVVVFDKSTEQILATLKGHTKKVTSVVFHPSQELVFSASPDATIRIWSVPNTSCVQVVRAHE 325

Human   307 SAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMD 371
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 SAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMD 390

Human   372 SQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF 436
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 SQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF 455

Human   437 EVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKF 501
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 EVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKF 520

Human   502 YSL 504
            |||
Mouse   521 YSL 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPF19	NP_055317.1	RING-Ubox_PRP19	3..56	CDD:438318	52/52 (100%)
		May mediate interaction with PSMC5. /evidence=ECO:0000250|UniProtKB:Q99KP6	68..223		154/173 (89%)
		Prp19	69..133	CDD:400774	63/82 (77%)
		WD 1	219..259		38/39 (97%)
		WD40 repeat	224..262	CDD:293791	36/37 (97%)
		WD40	<233..504	CDD:441893	267/270 (99%)
		WD 2	262..301		36/38 (95%)
		WD40 repeat	268..304	CDD:293791	33/35 (94%)
		WD 3	304..345		40/40 (100%)
		WD40 repeat	309..344	CDD:293791	34/34 (100%)
		WD 4	348..387		38/38 (100%)
		WD40 repeat	354..389	CDD:293791	34/34 (100%)
		WD 5	390..429		38/38 (100%)
		WD40 repeat	395..431	CDD:293791	35/35 (100%)
		WD 6	433..472		38/38 (100%)
		WD40 repeat	438..464	CDD:293791	25/25 (100%)
		WD 7	473..503		29/29 (100%)
		WD40 repeat	476..502	CDD:293791	25/25 (100%)
Prpf19	NP_001240772.1	RING-Ubox_PRP19	3..56	CDD:438318	52/52 (100%)
		Prp19	69..152	CDD:400774	63/82 (77%)
		WD40 repeat	243..281	CDD:293791	36/37 (97%)
		WD40	<252..523	CDD:441893	267/270 (99%)
		WD40 repeat	287..323	CDD:293791	33/35 (94%)
		WD40 repeat	328..363	CDD:293791	34/34 (100%)
		WD40 repeat	373..408	CDD:293791	34/34 (100%)
		WD40 repeat	414..450	CDD:293791	35/35 (100%)
		WD40 repeat	457..483	CDD:293791	25/25 (100%)
		WD40 repeat	495..521	CDD:293791	25/25 (100%)