DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRPF19 and prp-19

DIOPT Version :10

Sequence 1:NP_055317.1 Gene:PRPF19 / 27339 HGNCID:17896 Length:504 Species:Homo sapiens
Sequence 2:NP_001380015.1 Gene:prp-19 / 24104882 WormBaseID:WBGene00020423 Length:492 Species:Caenorhabditis elegans


Alignment Length:505 Identity:261/505 - (51%)
Similarity:349/505 - (69%) Gaps:16/505 - (3%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHP-IRPK 64
            ||.:|.||.|:.|.|.||.||.|:::||||.|:|||||||||::..|||:||:.:|.... ..|:
 Worm     1 MSFVCGISGELTEDPVVSQVSGHIFDRRLIVKFIAENGTDPISHGELSEDQLVSLKSGGTGSAPR 65

Human    65 PPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAARE 129
            ..|.||||::||.||||||.|||:||:||||||..||||||:|||||||||||:||:||:|||||
 Worm    66 NVSGTSIPSLLKMLQDEWDTVMLNSFSLRQQLQIARQELSHSLYQHDAACRVISRLSKELTAARE 130

Human   130 ALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTV 194
            ||:||||.....|...|...:..           :..|::..|:.||::|:..||.|||:|||.:
 Worm   131 ALSTLKPHTSAKVDDDVSIDESE-----------DQQGLSEAILAKLEEKSKSLTAERKQRGKNL 184

Human   195 PEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILAT 259
            ||.|.|.|||::.:|.|||.|:||...|||.|||:   ..|..||||.||.||::|...||::.|
 Worm   185 PEGLAKTEELAELKQTASHTGIHSTGTPGITALDI---KGNLSLTGGIDKTVVLYDYEKEQVMQT 246

Human   260 LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSS 324
            .|||.||:.:||.||......|||.|:.||:||..::|...::..|::.||.:||:|:|||:||:
 Worm   247 FKGHNKKINAVVLHPDNITAISASADSHIRVWSATDSSSKAIIDVHQAPVTDISLNASGDYILSA 311

Human   325 SDDQYWAFSDIQTGRVLTKVTDET-SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF 388
            |||.|||||||::|:.|.||:.|. |..::...:|||||||||||..|:.:||||||.:|..|.|
 Worm   312 SDDSYWAFSDIRSGKSLCKVSVEPGSQIAVHSIEFHPDGLIFGTGAADAVVKIWDLKNQTVAAAF 376

Human   389 PGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALG 453
            |||:..:.|||||||||||||.::|..|||||||||||.||...:....:.||.||.:||:|.:|
 Worm   377 PGHTAAVRSIAFSENGYYLATGSEDGEVKLWDLRKLKNLKTFANEEKQPINSLSFDMTGTFLGIG 441

Human   454 GTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 503
            |..||:...|.|:|::..::|||..|||.||.:|:.:.:..:|:||:.:|
 Worm   442 GQKVQVLHVKSWSEVVSLSDHSGPVTGVRFGENARSLVTCSLDKSLRVFS 491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRPF19NP_055317.1 RING-Ubox_PRP19 3..56 CDD:438318 30/52 (58%)
May mediate interaction with PSMC5. /evidence=ECO:0000250|UniProtKB:Q99KP6 68..223 84/154 (55%)
Prp19 69..133 CDD:400774 51/63 (81%)
WD 1 219..259 18/39 (46%)
WD40 repeat 224..262 CDD:293791 17/37 (46%)
WD40 <233..504 CDD:441893 136/272 (50%)
WD 2 262..301 17/38 (45%)
WD40 repeat 268..304 CDD:293791 13/35 (37%)
WD 3 304..345 24/40 (60%)
WD40 repeat 309..344 CDD:293791 22/34 (65%)
WD 4 348..387 20/39 (51%)
WD40 repeat 354..389 CDD:293791 20/34 (59%)
WD 5 390..429 27/38 (71%)
WD40 repeat 395..431 CDD:293791 27/35 (77%)
WD 6 433..472 14/38 (37%)
WD40 repeat 438..464 CDD:293791 11/25 (44%)
WD 7 473..503 12/29 (41%)
WD40 repeat 476..502 CDD:293791 10/25 (40%)
prp-19NP_001380015.1 RING-Ubox_PRP19 3..56 CDD:438318 30/52 (58%)
Prp19 70..134 CDD:400774 51/63 (81%)
SMC_prok_B <74..>201 CDD:274008 74/137 (54%)
WD40 <225..489 CDD:441893 134/263 (51%)
WD40 repeat 255..291 CDD:293791 13/35 (37%)
WD40 repeat 296..335 CDD:293791 24/38 (63%)
WD40 repeat 342..377 CDD:293791 20/34 (59%)
WD40 repeat 383..418 CDD:293791 26/34 (76%)
WD40 repeat 456..490 CDD:293791 12/33 (36%)

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