DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UBE2S and CG8188

DIOPT Version :9

Sequence 1:	NP_055316.2	Gene:	UBE2S / 27338	HGNCID:	17895	Length:	222	Species:	Homo sapiens
Sequence 2:	NP_001033852.1	Gene:	CG8188 / 32751	FlyBaseID:	FBgn0030863	Length:	209	Species:	Drosophila melanogaster

Alignment Length:	224	Identity:	127/224 - (56%)
Similarity:	152/224 - (67%)	Gaps:	24/224 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     3 SNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLFRMKLLLG 67
            ||||||.|..||.|.:|:..:...||:||||..||.|:||:|..|:||.|||||.|:||:||.|.
  Fly     6 SNVENLSPQTIRQVMRELQEMETTPPEGIKVLINESDVTDIQALIDGPAGTPYAAGIFRVKLTLN 70

Human    68 KDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLLIHPNPESALNEE 132
            ||||.:|||.|||||||||||.||||||||.||:||..:|||:|:|||||||||.||||||||||
  Fly    71 KDFPLTPPKAYFLTKIFHPNVAANGEICVNTLKKDWKPDLGIKHILLTIKCLLIVPNPESALNEE 135

Human   133 AGRLLLENYEEYAARARLLTEIHGGAGGPSGRAEAGRALASGTEASSTDPGAPGGPGGAEGPMAK 197
            ||::|||.|::|:.|||::||||                   .:.:....||.|......||..|
  Fly   136 AGKMLLERYDDYSQRARMMTEIH-------------------AQPAKCGVGAVGDAKDDGGPSTK 181

Human   198 KHAGERDKKLAAKKK----TDKKRALRRL 222
            |||| .||||..|||    .:|||.|:||
  Fly   182 KHAG-LDKKLQDKKKEKLLKEKKRMLKRL 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UBE2S	NP_055316.2	UQ_con	16..152	CDD:306648	91/135 (67%)
UBE2S	NP_055316.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..222		21/69 (30%)
CG8188	NP_001033852.1	COG5078	12..159	CDD:227410	98/165 (59%)
CG8188	NP_001033852.1	UBCc	16..155	CDD:238117	93/138 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159996
Domainoid	1	1.000	201	1.000	Domainoid score	I3027
eggNOG	1	0.900	-	-		E2759_KOG0423
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56676
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3299
Isobase	1	0.950	-	0	Normalized mean entropy	S899
OMA	1	1.010	-	-		QHG53499
OrthoDB	1	1.010	-	-		D1412570at2759
OrthoFinder	1	1.000	-	-		FOG0007037
OrthoInspector	1	1.000	-	-		oto89383
orthoMCL	1	0.900	-	-		OOG6_103684
Panther	1	1.100	-	-	LDO	PTHR24068
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4812
SonicParanoid	1	1.000	-	-		X5130
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750