Protein Alignment RPS6KA6 and Pkc53E

DIOPT Version :10

• Sequence 1: XP_016884912.1
• Gene: RPS6KA6 / 27330
• HGNCID: 10435
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Alignment Length: 458
• Identity: 154/458 - (33%)
• Similarity: 234/458 - (51%)
• Gaps: 64/458 - (13%)

Human    17 TMGLSTSAIWKNTRVEIVNPYEVKRKVKVN------------------GL-KMVDEP-------- 54
            |:....:.:|..|....:.|.:..|::.:.                  |: :::..|
  Fly   232 TIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLL 296

Human    55 -MEEGE------ADSCHDEGVVKEIP-----------ITHHVKEGYEKADPAQFELLKVLGQGSF 101
             .:|||      ||...|...:|:.|           ...|.....:......|..:||||:|||
  Fly   297 TQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSF 361

Human   102 GKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVR-TKMERDIL-VEVNHPFIVKLHYAFQTEGK 164
            |||.|..:|   .:.:|||:|:|||..:...|.|. |.:|:.:| :....||:|:||..|||..:
  Fly   362 GKVLLAERK---GSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDR 423

Human   165 LYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHI 229
            |:.:::::.|||:..::.:...|.|....||.||:|..|..||..||:|||||.:|:|||..||:
  Fly   424 LFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHV 488

Human   230 KLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKD 294
            |:.|||:.||::..:|...:||||.:|:|||::..:.:.:|.|||:||||::|||.|..||.|:|
  Fly   489 KIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGED 553

Human   295 RNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRL--GSEGVEEIKRHLFFANIDWDKLYK 357
            ..|....|....:..|:.||.||:...:....:.|..||  ||.|.|:::.|.||..|||:|:..
  Fly   554 EEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIEN 618

Human   358 REVQPPFKPASGKPDDTFCFDPEFTAK----TPKDSPGLPASANAHQL-FKGFSFVATSIAEEYK 417
            |||||||||......|...||.:||::    ||.|...:   .|..|. |.|||:    :..||.
  Fly   619 REVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFM---MNLDQSEFVGFSY----MNPEYV 676

Human   418 ITP 420
            .:|
  Fly   677 FSP 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA6	XP_016884912.1	STKc_RSK_N	94..408	CDD:270734	134/322 (42%)
		STKc_RSK4_C	438..732	CDD:271079
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	10/74 (14%)
		STKc_cPKC	353..672	CDD:270739	134/328 (41%)