Protein Alignment RPS6KA6 and for

DIOPT Version :10

• Sequence 1: XP_016884912.1
• Gene: RPS6KA6 / 27330
• HGNCID: 10435
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 335
• Identity: 130/335 - (38%)
• Similarity: 197/335 - (58%)
• Gaps: 15/335 - (4%)

Human    65 DEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL 129
            |||.::.    ..:.|.:...:.....::..||.|.||:|.||  :|..|:.:.:|:|.:||:.:
  Fly   756 DEGAMER----RKINEEFRDINLTDLRVIATLGVGGFGRVELV--QTNGDSSRSFALKQMKKSQI 814

Human   130 -KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVK 193
             :.|.:.....|::|:.|.|..|||||...|:.:..||::::...||:::|.|..:..|.:...:
  Fly   815 VETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTR 879

Human   194 FYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMA 258
            ||.|.:..|.|:||...|:||||||||:||:|.|::||.|||.:|: :...:|.::||||.||:|
  Fly   880 FYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKK-LQTGRKTWTFCGTPEYVA 943

Human   259 PEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKA--KLGMPQFLSAEAQSLL 321
            |||:..|||..|||:||.||||||:||||.||.|.|...|.|:|||.  .:..|:.::..|.:|:
  Fly   944 PEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLI 1008

Human   322 RMLFKRNPANRLGSE--GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFD---PEF 381
            :.|.:.|||.|||.:  |:.||::|.:|....|..|....::||.|||.....||..||   |:.
  Fly  1009 KKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDP 1073

Human   382 TAKTPKDSPG 391
            ....|.|..|
  Fly  1074 EGPPPDDVTG 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA6	XP_016884912.1	STKc_RSK_N	94..408	CDD:270734	126/306 (41%)
		STKc_RSK4_C	438..732	CDD:271079
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		CAP_ED	520..629	CDD:237999
		CAP_ED	638..754	CDD:237999
		STKc_cGK	783..1043	CDD:270724	112/262 (43%)