Protein Alignment RPS6KA6 and aurA

DIOPT Version :10

• Sequence 1: XP_016884912.1
• Gene: RPS6KA6 / 27330
• HGNCID: 10435
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 319
• Identity: 105/319 - (32%)
• Similarity: 164/319 - (51%)
• Gaps: 22/319 - (6%)

Human    27 KNTRVEIVNPYEVKRKVKVNGLK-------MVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEK 84
            |.|..|...|..|....|...|.       ..:...|.|.|.|..::...|........|:.:|.
  Fly    87 KKTTSEFAAPAPVAPIKKPESLSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKPKKTWEL 151

Human    85 ADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL---KVRDRVRTKMERDILVE 146
            .:   |::.::||:|.||.|:|.|:|   ::..:.|:|||.|..:   .|..:||.::|  |...
  Fly   152 NN---FDIGRLLGRGKFGNVYLAREK---ESQFVVALKVLFKRQIGESNVEHQVRREIE--IQSH 208

Human   147 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL--FTEEDVKFYLAELALALDHLHQL 209
            :.||.|::|:..|..:.::||||::...|.:|..|..:.:  |.|.....|:..|..||.:||:.
  Fly   209 LRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHER 273

Human   210 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWW 274
            .|::||:||||:||...|.:|:.|||.|..  :......:.||||:|:.||:|..:.|:::.|.|
  Fly   274 DIIHRDIKPENLLLGHKGVLKIADFGWSVH--EPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLW 336

Human   275 SYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRL 333
            |.|||.||:|.|..||..|:.:||...|||....:|:.:|..|..|:..|...||.:||
  Fly   337 SLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRL 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA6	XP_016884912.1	STKc_RSK_N	94..408	CDD:270734	90/245 (37%)
		STKc_RSK4_C	438..732	CDD:271079
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	91/253 (36%)