DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA6 and JIL-1

DIOPT Version :9

Sequence 1:	XP_016884912.1	Gene:	RPS6KA6 / 27330	HGNCID:	10435	Length:	762	Species:	Homo sapiens
Sequence 2:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster

Alignment Length:	682	Identity:	246/682 - (36%)
Similarity:	354/682 - (51%)	Gaps:	60/682 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    90 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL--KVRDRVRTKMERDILVEV-NHPF 151
            |::::|||.|::|:||||||.|..|||:|||||||.|.::  |.:....||.||.:|..: .:||
  Fly   261 FKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPF 325

Human   152 IVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDL 216
            :|.||||||:..||||:|||..||::||.|.....|.|..|:.|:||:.|||:.||||||:|||:
  Fly   326 LVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDI 390

Human   217 KPENILLDEIGHIKLTDFGLSK-ESVDQEKKAYSFCGTVEYMAPEVVNR--RGHSQSADWWSYGV 278
            |.||||||..|||.|:|||||| .:.:.|.:|:|||||:||||||::..  .||..:.||||.||
  Fly   391 KLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGV 455

Human   279 LMFEMLTGTLPFQGKD----RNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EG 337
            |.||:|||..||...|    ::|....|.|.:..:|...||.|:..:..:.::||..|||.  ..
  Fly   456 LTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRD 520

Human   338 VEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLF 402
            ..|||.|.||..|:|.:|..:..:.|:||.....||...|..|||.:.|:| |...|..:..:||
  Fly   521 ASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPED-PECDAPPSRIRLF 584

Human   403 KGFSFVATSIAEEYKITPITSANVLPIVQIN---GNAAQFGEVYELKEDIGVGSYSVCKRCIHAT 464
            :|:::||....|:.:     ..|...|...|   .|.....:..||......|:|..|...:.::
  Fly   585 RGYTYVAPEHLEQMR-----RDNHCEIQYFNTGLQNIPCRPDDLELGTRTSNGAYGTCHFVVDSS 644

Human   465 TNMEFAVKIIDKSKRDPSEE---IEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRI 526
            |::.|..|||..||..|||.   |...:....|.||::....|.:....::|.:.:.|.||...|
  Fly   645 TDLVFLAKIIPLSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASI 709

Human   527 LKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFA----- 586
            .    ..|....:|...:...|.::|.:..:|.||||.||::  |:....::::.|||.|
  Fly   710 R----MDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMF--ENREDRTVKLIDFGSACYNNR 768

Human   587 -KQLRGENGLLLTPCYTANFVAPEVLMQQG---YDAACDIWSLGVLFYTMLAGYTPFANGPNDTP 647
             |..:.:      |.||.::..||:|....   |..|.||:.||...||||.|:.|:....:|..
  Fly   769 FKSWKDK------PRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVD 827

Human   648 ------EEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQL 706
                  .|:..|:..|.|:.....|::.|...:.|:|..|..||..|.|...||...|:.:....
  Fly   828 HSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSND 892

Human   707 PNDQPKRNDVSHVVKGAMVATYSALTHKTFQP 738
            |       ||..::...||...|..|.:  ||
  Fly   893 P-------DVDIILPQQMVVDLSEDTME--QP 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA6	XP_016884912.1	None
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	132/268 (49%)
		STKc_MSK_N	266..533	CDD:270735	133/266 (50%)
		S_TK_X	532..591	CDD:214529	19/59 (32%)
		S_TKc	632..886	CDD:214567	74/265 (28%)
		PKc_like	632..885	CDD:304357	74/264 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750