Protein Alignment RPS6KA6 and S6kII

DIOPT Version :10

• Sequence 1: XP_016884912.1
• Gene: RPS6KA6 / 27330
• HGNCID: 10435
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Alignment Length: 751
• Identity: 424/751 - (56%)
• Similarity: 532/751 - (70%)
• Gaps: 69/751 - (9%)

Human    53 EPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQ 117
            ||:.|.|     :|..:||:     :|||::||||:|||||:|||:|||||||||||..|.|||.
  Fly   172 EPLYETE-----NEFELKEV-----IKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGT 226

Human   118 LYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLS 182
            ||||||||||:|||:||||:..||.||.:|.|.|||:|||||||.||||||||||||||:|||||
  Fly   227 LYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLS 291

Human   183 KEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKA 247
            |||:||||||||||||||||::|||.|||:|||||||||||||.|||.||||||||:.:| ..|.
  Fly   292 KEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKT 355

Human   248 YSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQF 312
            |||||||||||||:|||:||..:|||||:||||:|||||.|||.|:.|.||||.||::|||||:.
  Fly   356 YSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPEN 420

Human   313 LSAEAQSLLRMLFKRNPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTF 375
            ||.|||||||.||||||.|||  |::|:.:||.|.|||.|||.:|.:::|:|||.||..: ||.|
  Fly   421 LSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAF 484

Human   376 CFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVA---------------TSIAEEYKITPITSAN 425
            .||.|:|:|:|:||||.|.||:||::|:||||||               ||.:..:.|.||.:|.
  Fly   485 YFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAP 549

Human   426 V-----LPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK--------- 476
            |     ||.| :.||   |...|.|.:::|.|::|||:.|.|..:...:|||:|:|
  Fly   550 VGAPRTLPGV-LPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTS 610

Human   477 SKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDIL 541
            :..|..||:||::|||.||||:||..|::|....|||.:|:||||||||||......|.|||.:|
  Fly   611 TSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVL 675

Human   542 YVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFV 606
            ..|:..|.|||..|||||||||||::|.....:.:::::||.|||||||.:||||:|||||||||
  Fly   676 RTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFV 740

Human   607 APEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISD 671
            |||||.:||||.||||||||||.|.||:|.||||:.|||:|:.||.|||:|:...:...|..||.
  Fly   741 APEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISV 805

Human   672 GAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQ-------------------LPNDQPKRNDVS 717
            .||:||..|||:.|..|.||.:||:|.|:  |:|                   |...|.::|.:|
  Fly   806 PAKELLRQMLHIVPENRPTAARILEHDWL--REQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHIS 868

Human   718 HVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRS 753
            ..::||:.||:.|:.......| .||..|.||:||:
  Fly   869 MALRGAVDATFRAIAIPQAANV-GPVELSMLAKRRA 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA6	XP_016884912.1	STKc_RSK_N	94..408	CDD:270734	227/315 (72%)
		STKc_RSK4_C	438..732	CDD:271079	155/321 (48%)
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	227/315 (72%)
		STKc_RSK_C	567..883	CDD:270993	154/317 (49%)