DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBMX and sap-49

DIOPT Version :9

Sequence 1:	NP_002130.2	Gene:	RBMX / 27316	HGNCID:	9910	Length:	391	Species:	Homo sapiens
Sequence 2:	NP_001379265.1	Gene:	sap-49 / 4363023	WormBaseID:	WBGene00004723	Length:	388	Species:	Caenorhabditis elegans

Alignment Length:	350	Identity:	93/350 - (26%)
Similarity:	121/350 - (34%)	Gaps:	109/350 - (31%)

- Green bases have known domain annotations that are detailed below.

Human     5 DRPGKLFIGGLNTETNEKALEAVFGKYGRIVEV-LLMKDRETNKSRGFAFVTFESPADAKDAARD 68
            |....:|:|.|:.|.:||.|...|..:|.|::| .:|:|.::..|:||||:.|.| .:|.|.|.:
Worm    97 DVGANIFVGNLDPEVDEKLLYDTFSAFGVILQVPKIMRDVDSGTSKGFAFINFAS-FEASDTALE 160

Human    69 -MNGKSLDGKAIKVEQATKPSFESGRRGP----------PPPPRSR--------------GPPRG 108
             |||:.|..:||.|..|.|...:..|.|.          |..|:.|              ..|..
Worm   161 AMNGQFLCNRAITVSYAFKRDSKGERHGTAAERMLAAQNPLFPKDRPHQVFSDVPLGVPANTPLA 225

Human   109 LRGGRG-------GSGGTRGPPSRGGHMDDGGYSMNF--------NMSSSRGPLPVKRG------ 152
            :.|...       |..|.:.||..|  |...||...:        :::....|:|...|
Worm   226 MPGVHAAIAAHATGRPGYQPPPLMG--MAQSGYQGQYPPVPPPPPSVTPMPPPMPPTPGMTPRPP 288

Human   153 PPPRSGGPPPKRSAPSGPVRSSSGMGGR---APVSR-GRDSYGGPPRREPLPSRRDVYLSPRDDG 213
            |||.||..||....|.|......||.|.   .|.|| |....||.|...| |..|
Worm   289 PPPSSGMWPPPPPPPPGRTPGPPGMPGMPPPPPPSRFGPPGMGGMPPPPP-PGMR---------- 342

Human   214 YSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRDRDYSDHPSG 278
                       ||.....   .||||               |||.|    .|.        :|..
Worm   343 -----------YPGGMPP---PPPPR---------------YPSAG----PGM--------YPPP 366

Human   279 GSYRDSYESYGNSRSAPPTRGPPPS 303
            ...|......|:....||   ||||
Worm   367 PPSRPPAPPSGHGMIPPP---PPPS 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBMX	NP_002130.2	RRM_RBMX_like	7..86	CDD:409816	31/80 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..391		71/292 (24%)
		dnaA	165..>306	CDD:237605	34/142 (24%)
		RBM1CTR	173..217	CDD:400429	13/47 (28%)
		Necessary for the association to nascent RNAPII transcripts and nuclear localization	186..236		9/49 (18%)
		Necessary for RNA-binding	333..391
sap-49	NP_001379265.1	RRM1_SF3B4	15..88	CDD:409771
sap-49	NP_001379265.1	RRM2_SF3B4	99..181	CDD:409772	32/82 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910