Protein Alignment RBMX and Saf-B

DIOPT Version :10

• Sequence 1: NP_002130.2
• Gene: RBMX / 27316
• HGNCID: 9910
• Length: 391
• Species: Homo sapiens
• Sequence 2: NP_733041.2
• Gene: Saf-B / 42958
• FlyBaseID: FBgn0039229
• Length: 928
• Species: Drosophila melanogaster
• Alignment Length: 624
• Identity: 137/624 - (21%)
• Similarity: 186/624 - (29%)
• Gaps: 251/624 - (40%)

Human    10 LFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKSL 74
            |::.||:|.|....|:|:|.|:|:::...::.:..|..:|.:.:||..|.|||.....:::...|
  Fly   314 LWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPGTRCYGYVTMSSSADASRCIENLHRTEL 378

Human    75 DGKAIKVEQATKPSFE---SGRRGPPPPPRSRGPPR-----GLRGGRG-GSGGTRGPPSRGG--- 127
            .|:.|.||: ||....   :.:.|....|...|..:     |.:.|.| ||....|...:||
  Fly   379 HGRIISVER-TKNEIGGSLNSKEGKGKAPGDAGNKKKEDDSGKKSGSGKGSSSNSGDDKKGGDGN 442

Human   128 -----------------------HMDDGGYSM-------NFNMSSSRGPLPVKRGPPPRS----- 157
                                   ..||.|.|:       :....|::|....:.|..||.
  Fly   443 GDSKSVGGDLKRDGKESNRARSRRNDDRGKSLASQDRPRHDRERSAKGSQDHRSGRNPRDVDREI 507

Human   158 -------------------------------------GGPPPKRSAPSGP--------------- 170
                                                 .....:|.|....
  Fly   508 QQRQRERERRQREMLSYQKIREERERQRLRERERELREEERRRREARERQRIEEERLQEERRKLA 572

Human   171 ------------------------------------------VRSSSGMGGRAPVSRGRDSYGG- 192
                                                      :.|....|.|....|..|.||.
  Fly   573 VERERLEREKAELLRMERERQKLEREKIELERLELKRQQMKIMESRDDPGKRGVSKRADDRYGDV 637

Human   193 -------------PPRREP-LPSRRDVYLSPRDD---GYSTK---DSYSSR----DYPSSRDTRD 233
                         |||.:. |.|.|..|....||   ..|||   |.|||.    ||.|.|:  |
  Fly   638 TDRKRTAIFDAPPPPRFDTNLVSSRSTYDKKHDDYGSSSSTKRVLDDYSSSSKRLDYSSKRN--D 700

Human   234 YAPPP-------RDYT------YRDYGHSSS--RDDY-----------------PSRGY------ 260
            |:...       .|||      ..||..|||  ||||                 .|..|
  Fly   701 YSSSSGSKRGAVDDYTAVPTKRSNDYSASSSSKRDDYKRDEVRHLPLSGTVGGGSSSSYLHKNNT 765

Human   261 -----------SDRDGYGRDRDYSDHPSGGSY-RDSYESYGNSRSAPPTRGP------------- 300
                       ::..|.|...:.||..:..|| ||...|.||.|....:.|.
  Fly   766 AGGGAGSYVHKNNTSGTGGRYNDSDRSNTSSYRRDDSHSLGNKRYDNSSGGGGAYGSSSNSVNIW 830

Human   301 PPSYGGSSRYDDYSSSRDGYGGSRDSYSSS--RSDLYSSGR--------DRVGRQERGLPPSMER 355
            .||.||||   .:..|..|.|....||.::  .|:::|:..        |...||   :|...:|
  Fly   831 APSSGGSS---SHLGSGGGGGNQIKSYGNNGMSSNMHSTNSWQKSAPVDDNGWRQ---VPARFDR 889

Human   356 GYPPPRDSYSSSSRGAPRGGGRGGSR--SDR-GGGRSRY 391
            ||......|...|.|...||..|.||  .|| .|..|||
  Fly   890 GYNERSTGYQGQSGGGGAGGMYGASRPAQDRYSGPVSRY 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBMX	NP_002130.2	RRM_RBMX_like	7..86	CDD:409816	23/75 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..391		119/571 (21%)
		dnaA	165..>306	CDD:455861	59/285 (21%)
		RBM1CTR	173..217	CDD:400429	17/61 (28%)
		Necessary for the association to nascent RNAPII transcripts and nuclear localization	186..236		25/74 (34%)
		Necessary for RNA-binding	333..391		20/68 (29%)
Saf-B	NP_733041.2	SAP	11..42	CDD:460424
		2A1904	<16..>270	CDD:273344
		RRM_SF	311..386	CDD:473069	21/71 (30%)
		SWIRM-assoc_1	<588..618	CDD:465142	0/29 (0%)