DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RAB30 and Rab30

DIOPT Version :9

Sequence 1:	NP_001272988.1	Gene:	RAB30 / 27314	HGNCID:	9770	Length:	203	Species:	Homo sapiens
Sequence 2:	NP_001245926.1	Gene:	Rab30 / 33988	FlyBaseID:	FBgn0031882	Length:	223	Species:	Drosophila melanogaster

Alignment Length:	210	Identity:	134/210 - (63%)
Similarity:	164/210 - (78%)	Gaps:	13/210 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     3 MEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEINGEKVKLQIWDTAG 67
            ||||.|||||||:|||||||||||||||||||||||||||||||||||||:.|||:|||||||||
  Fly     1 MEDYKFLFKIVLVGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEVEGEKIKLQIWDTAG 65

Human    68 QERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREV 132
            |||||||||||||||:||||.|||:|:.:|.|||:|||||::||::||:.:|||||.| .:.||:
  Fly    66 QERFRSITQSYYRSAHALILVYDISCQPTFDCLPDWLREIQEYANSKVLKILVGNKTD-RDDREI 129

Human   133 SQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQ---NTLVNNVSSPLPGEGKSI 194
            ..|..|||::..|||:|||||||::|||:||.::|..||.:||.   ::.....::....||.||
  Fly   130 PTQIGEEFAKQHDMYFLETSAKEAENVERLFYEIAAELIGQARSKDGSSSAAAAAAQRQSEGSSI 194

Human   195 ---------SYLTCC 200
                     :...||
  Fly   195 GLGSFSAKAAQSNCC 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAB30	NP_001272988.1	Rab30	3..171	CDD:133314	124/167 (74%)
RAB30	NP_001272988.1	Effector region. /evidence=ECO:0000250	38..46		7/7 (100%)
Rab30	NP_001245926.1	Rab30	1..168	CDD:133314	124/167 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160291
Domainoid	1	1.000	247	1.000	Domainoid score	I2168
eggNOG	1	0.900	-	-		E1_KOG0095
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22815
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3028
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1149105at2759
OrthoFinder	1	1.000	-	-		FOG0007336
OrthoInspector	1	1.000	-	-		oto89904
orthoMCL	1	0.900	-	-		OOG6_110019
Panther	1	1.100	-	-	LDO	PTHR47977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4448
SonicParanoid	1	1.000	-	-		X5453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790