DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF544 and CG6689

DIOPT Version :9

Sequence 1:	NP_001374339.1	Gene:	ZNF544 / 27300	HGNCID:	16759	Length:	769	Species:	Homo sapiens
Sequence 2:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	635	Identity:	154/635 - (24%)
Similarity:	242/635 - (38%)	Gaps:	192/635 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    46 SGLFRCREEMEAR--------SMLVPPQASVCFEDVAMAFTQEEWEQLDLAQRTLY--REVTLET 100
            ||..|.|:|...|        .:|...:|.:...: |.:|.|:          ::|  ..||:|.
  Fly    99 SGSDRARKERSQRRRNQELVAELLAEEEAKLIHPE-ATSFEQD----------SVYLSETVTMEL 152

Human   101 WEHIVSLGLFLSKSDVISQLEQEEDL--CRAEQEAPRDWKATLEENRLNSEKDRAREELSHHVEV 163
                          |.:|..|:.|:|  ||.   ...|:.|   :.|.....|.|...|..|:||
  Fly   153 --------------DPLSGEEKLEELQKCRT---CYNDFTA---DFRAKDLFDPANSVLLFHIEV 197

Human   164 YRSG------PEEPPSL--VLGKVQDQSNQLREHQENSLRFMVLTSERLFAQ----REHCELELG 216
            . ||      |:||..:  ......||:...||        |.:::|...:|    .:..::|..
  Fly   198 I-SGVWISHKPDEPRLMCPACKSALDQAIDFRE--------MCISTELKLSQAKPSTDEVQIEAE 253

Human   217 GGYSLPSTLSLLPTTLPTSTGFPKPNSQVKELKQNSAFINHEKNGADGKHCESHQCARAFCQS-- 279
            ....:.|...|:..|         .|:.|:|::....  :|.::.|......|.:......:|
  Fly   254 NENPISSDHDLISDT---------ENTNVEEIEDAGG--DHVEDEATSDDQTSQEAVDEVAESPA 307

Human   280 ------------IYLSKLGNVETGKKNPYEYIVSGDSLNYGSSLCFHGRTFSVKKSDDCKDYGNL 332
                        |: .:|.:..|||:..        .|..|:.:.      |..|:.:
  Fly   308 AQDPLSVALGAKIF-KELLDQYTGKEKA--------RLRKGAPIA------SKPKAKE------- 350

Human   333 FSHSVSLNEQKPVHFGKSQYECDECRETCSESLCLVQTERSGPGETPFRCEERCAAFPMASSFSD 397
                .:..||||                          :||...:|.   |||
  Fly   351 ----KAAGEQKP--------------------------KRSANPKTK---EER------------ 370

Human   398 CNII---QTTEKPS--VCNQCGKSF--SCCKLIHQRTHTGEKPFECTQCGKSFSQSYDLVIHQR- 454
             |:|   |...||.  ||:|||::|  |....||...||..|.::||:|.|:|..:|...:|.|
  Fly   371 -NLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRI 434

Human   455 THTGEKPYECDLCGKSFTQRSKLITHQ-RIHTGEKPYQCIECRKSFRWNSNLIVHQRIHTGEKP- 517
            .|.||.|:.|..|.::|........|: .:|...               ..||| :||:....|
  Fly   435 RHRGETPFACGFCSETFAYPGARQKHESEVHNAA---------------PRLIV-KRINPKPMPK 483

Human   518 ------YECTHCGKSFSQSYELVTHKRTHTGEKPFKCTQCGKSFSQKYDLVVHQRTHTGEKPYEC 576
                  |:|..|.|.::..|.|..|.::||....:||.:|.||:|....|..|:.||. ::|.:|
  Fly   484 PRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQC 547

Human   577 NLCGKSFSQSSKLITHQRIHTGEKPYQCIECGKSFRWNSNLVIH--QRIH 624
            ::|.|.|.|.::|..|:.|||||:||.|..|..:||:..|:..|  .::|
  Fly   548 DVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANSKMH 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF544	NP_001374339.1	KRAB	68..127	CDD:214630	12/62 (19%)
		C2H2 Zn finger	410..428	CDD:275368	8/19 (42%)
		zf-H2C2_2	424..445	CDD:404364	9/20 (45%)
		C2H2 Zn finger	436..456	CDD:275368	8/20 (40%)
		COG5048	460..>753	CDD:227381	53/175 (30%)
		C2H2 Zn finger	464..484	CDD:275368	4/20 (20%)
		C2H2 Zn finger	492..512	CDD:275368	4/19 (21%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	548..568	CDD:275368	7/19 (37%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	6/21 (29%)
		C2H2 Zn finger	632..652	CDD:275368
		C2H2 Zn finger	660..680	CDD:275368
		C2H2 Zn finger	688..708	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	22/87 (25%)
		zf-C2H2	385..407	CDD:278523	9/21 (43%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	6/22 (27%)
		C2H2 Zn finger	575..591	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010