DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CNTN6 and rig-6

DIOPT Version :9

Sequence 1:NP_001276009.1 Gene:CNTN6 / 27255 HGNCID:2176 Length:1028 Species:Homo sapiens
Sequence 2:NP_001022014.1 Gene:rig-6 / 173828 WormBaseID:WBGene00016354 Length:1196 Species:Caenorhabditis elegans


Alignment Length:1082 Identity:275/1082 - (25%)
Similarity:454/1082 - (41%) Gaps:173/1082 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    27 IFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDI-DFTMS-YHYRLDGGSLAINSP 89
            |:....||..:        :.|.|...|.|.|...|.:|..:: ..:|| ..|.|.||:|.:.:.
 Worm   154 IYFHPRHDADY--------IALPCTVQGNPKPTVAWYKNDVEVLSPSMSNVSYLLSGGNLLVPAS 210

Human    90 HTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHF-GDL 153
            .| .....:.|.|.|.||.:.|....|:.::|:.|........|:..| |..|.|..|.|. ..|
 Worm   211 ST-LAYSSFHCTARNSLGEVRSPPILLKPSFIDPFRPHRLDVYSLATG-GAKLDCDAPAHQPKSL 273

Human   154 SYAWTF-NDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQR 217
            :|:|.: :.....:.::.|:|:|.: |.|:.:.|...|..:|.|.::....|....||...|:..
 Worm   274 TYSWLYGSSTDRILSQNERKFISLD-GTLFFSYVTAEDEDSYACSLSVYSTQSGHYGPFFRLISS 337

Human   218 TDGVMGE-YEPKIEVR----FPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSK 277
            |..::.. :.||::..    |||..:..  .|:.|||||..:|:|...|.|:||.|:|.:...|.
 Worm   338 TPKLVNSTFPPKLDSTQPQIFPEDPKVG--DSIYLECFAYASPLPQYKWSRVDGKPIPARSHISN 400

Human   278 SQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKAS 342
            ...:|:|......|.|.|:|:|.|..|....:..:...|||...|.:.:..:....|:.:||..|
 Worm   401 YGRVLKIEKVNYGDAGKYKCVAMNAFGSAAGEVHVKLRAPPSILQGLHDRLVPTESNVSFECLLS 465

Human   343 GKPNPWYT---WLKNGERLNP-------EERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYA 397
            ...:  |:   |.|:.:.:.|       .:|::|::..|.:...:.:|||||||.|.|......:
 Worm   466 NADS--YSSVEWFKDAKPIVPLLLPAEKRKRLKIDHNVLHLKFADETDSGVYQCVASNDVGSSSS 528

Human   398 NAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISW-KRGTETLRQSKRIFLLED 461
            :|.|.|..|||.|..:.:.:|.|...|..:.|.|...|.||....| ..|...|.|..|| ..|:
 Worm   529 SALLTVKDSAPVFPPNAMSRKVFAAFGSTVSIPCIFEASPRFHGKWADAGGSKLPQKGRI-RDEE 592

Human   462 GSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQV--- 523
            |.:.|..:...|||.:.|.|.|:.|.|.....||     |:..|..|.:....|::.:.|:|   
 Worm   593 GVISIEKVLHEDAGLFFCTAHNKLGKAHAQVQLI-----VVNKPSIKTNFLDEETVNMSCEVELT 652

Human   524 ----SHDPSIEVVFVWFFNG----DVIDLKKGVAHFERIGGESVGDLMIRNIQL---------HH 571
                :..|  |.:|.|..|.    :...||..| |.::.|.:  |..:.:.:.|         ..
 Worm   653 CENSAECP--EALFEWKINDRPAKEYPSLKSKV-HEKKSGHK--GRHLKQKVDLEVPKSLAGSRQ 712

Human   572 SGKYLCTVQTTLESLSAVADIIVRGPPGP-PEDVQVEDISSTTS-----QLSWRAGP------DN 624
            .|::.|:      ||...:...|..|..| |..:.||.:.....     :|.||..|      |:
 Worm   713 IGRFACS------SLYGGSSEFVTKPQLPSPIALTVEQMDEDGKKKKMFRLRWRLPPQHRDTRDH 771

Human   625 NSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEP 689
            :..::.:.::.||..:..|:| |....:.|.:..:.||..|.|..||:|||.:..|..|||||.|
 Worm   772 SPKVEGYLVELRTRKNRKWRA-AERQLVGNMEKDSITVENLLPNTEYQFRVRSVESAAIGEPSIP 835

Human   690 SELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEEL---QNGEGFGYIIMF--RPVGSTTWS 749
            |:.::|....|.....|:.........|::.|:  |.|:   .:|:...|.:.:  ..||.....
 Worm   836 SDWVKTAPGAPSETIDNLKWRSLDSQTLLVEWQ--PIEIGQESSGDNLRYRVSWSEATVGKNATD 898

Human   750 KEKVSSVESSRFVYRN-------ESIIPLSPFE------VKVGVYNNEGEGSLSTVTIVYSGEDE 801
            ..|:|:.:..   :.|       ::|:.|:..|      :.|...|::|.||:.|.||.:.....
 Worm   899 DMKLSNQDDD---FENHLDSDQPQAILKLNTTEGCRMVVLAVRPVNDQGNGSVGTDTIAFLNSHG 960

Human   802 PQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESM-IGKIRVSGNVTTKN 865
            ........:::..:||.:.:||   .|: ||...          |:|.:: |..|.:||:..:..
 Worm   961 ELKKVSLHNVKPINASHVNISW---TWD-NTSDC----------DTKHAVQITCINLSGSEISAT 1011

Human   866 IT---------GLKANTIYFASVRAYNTAGT-GPSSPPVNVTTKKSPPSQPPANIAWKLTNSKL- 919
            :.         ||:|.|.|...::|.:..|: ||:|....:.||:.|||:.|  :..||...:: 
 Worm  1012 VASDRIFWMLGGLEAETAYDCDLKAIDNHGSFGPASKKFRIHTKQHPPSETP--LIGKLMMKQMK 1074

Human   920 -----CLNWEHVKTME-NESE-VLGYKILYRQNRQSKTHILETNNTSAELLVPFEE--------- 968
                 .|.|..::..: |.:| ..||||.        .:|.||...:.||.:|.:.         
 Worm  1075 DTYTTILEWSSIELQKPNRTENGCGYKIF--------IYISETATEAIELDMPLQRLSDRRNPSA 1131

Human   969 ---------DYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSRG 1001
                     .|.|::...:.||.|..||    |:...|.|.|
 Worm  1132 RLDGLKLMYMYTIKVAGYNPGGIGPISE----PRSIRLGSPG 1169

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CNTN6NP_001276009.1 Ig 26..118 CDD:325142 25/92 (27%)
Ig 120..214 CDD:325142 24/95 (25%)
Ig 227..315 CDD:325142 29/91 (32%)
Ig 319..403 CDD:325142 23/93 (25%)
Ig 424..496 CDD:325142 24/72 (33%)
Ig 515..598 CDD:325142 20/102 (20%)
FN3 598..691 CDD:238020 31/104 (30%)
FN3 703..796 CDD:238020 23/110 (21%)
FN3 805..898 CDD:238020 23/103 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 887..908 8/21 (38%)
FN3 906..991 CDD:238020 24/110 (22%)
rig-6NP_001022014.1 Ig 153..237 CDD:299845 24/91 (26%)
Ig 240..335 CDD:299845 24/96 (25%)
Ig 358..427 CDD:299845 26/70 (37%)
IG_like 363..436 CDD:214653 24/74 (32%)
I-set 441..534 CDD:254352 24/94 (26%)
IGc2 456..524 CDD:197706 20/69 (29%)
I-set 547..627 CDD:254352 27/85 (32%)
Ig 552..627 CDD:299845 25/80 (31%)
FN3 737..839 CDD:238020 31/102 (30%)
fn3 970..1047 CDD:278470 22/90 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I8367
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46028
OrthoDB 1 1.010 - - D292460at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100978
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3370
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.960

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