DRSC/TRiP Functional Genomics Resources

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Protein Alignment PCDH17 and ft

DIOPT Version :10

Sequence 1:NP_001035519.1 Gene:PCDH17 / 27253 HGNCID:14267 Length:1159 Species:Homo sapiens
Sequence 2:NP_477497.1 Gene:ft / 33627 FlyBaseID:FBgn0001075 Length:5147 Species:Drosophila melanogaster


Alignment Length:1516 Identity:333/1516 - (21%)
Similarity:518/1516 - (34%) Gaps:492/1516 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    22 NYSVPEEQGAGTVIGNI-GRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLY 85
            ::.:||....|..:|.| .|||.|            |::...||.|:.:.|..:..::..:|:|.
  Fly  1928 SFDIPENAQRGYQVGQIVARDADL------------GQNAQLSYGVVSDWANDVFSLNPQTGMLT 1980

Human    86 TKQRIDRESL--------CRHNAKCQLS--LEVFANDKEICMIKVEIQDINDNAPSFSSDQIEMD 140
            ...|:|.|.:        .:.|.:..||  :.|:.|          :.|:|||||.|.......:
  Fly  1981 LTARLDYEEVQHYILIVQAQDNGQPSLSTTITVYCN----------VLDLNDNAPIFDPMSYSSE 2035

Human   141 ISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDD-HGLFGLD----VKSR-------------- 186
            :.||....|.....||.|.|:|.|||..|.:|..| ...||:|    :::|              
  Fly  2036 VFENVPIATEVVTVSAKDIDSGNNGLIEYSITAGDVDSEFGIDSNGTIRTRRNLDREHRSTYTLT 2100

Human   187 ----------------------------------------------------------------- 186
                                                                             
  Fly  2101 VTARDCADEFASFSELEETQLKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVTILIKDVNDEVP 2165

Human   187 ------------------------------------------------GDGTKFP--------EL 195
                                                            |.....|        :|
  Fly  2166 VFISANETAIMENVAINTVVIAVKAVDNDEGRNGYIDYLMKEARDEDMGQSDPLPFSLNPTDGQL 2230

Human   196 VIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGT 260
            .:..|||||.::.:.|.:||.|.||||:|...|:.::::|.|||||||:...|...:.|||.:|.
  Fly  2231 RVVDALDRELRSSYLLNITARDRGEPPQSTESQLLIRILDENDNSPVFDPKQYSASVAENASIGA 2295

Human   261 VVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARD 325
            :|:.::|||.|||.||.:.||.  .:.|:..: |||...||::||..||:||......:.|:|.|
  Fly  2296 MVLQVSATDVDEGANGRIRYSI--VLGDQNHD-FSISEDTGVVRVAKNLNYERLSRYSLTVRAED 2357

Human   326 LG-PNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPP-GTVIALVRVTDRDSGK-NGQL 387
            .. .||.....::|:.::|.|||.|:..........:....|| |..:..|...|.|:.. |.| 
  Fly  2358 CALENPAGDTAELTINILDINDNRPTFLDSPYLARVMENTVPPNGGYVLTVNAYDADTPPLNSQ- 2421

Human   388 QCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTD-------RPLDRETQDEYNVTIVAR 445
                                  |.:.|:|...:.:.:...       :|||||.|.||.:|:||.
  Fly  2422 ----------------------VRYFLKEGDSDLFRINASSGDIALLKPLDREQQSEYTLTLVAM 2464

Human   446 DGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYS 510
            |.|||||..|....:::.|.|||.|.|....|...|.||...|.::.:..|.|.|.|.|..:.::
  Fly  2465 DTGSPPLTGTGIVRVEVQDINDNDPVFELQSYHATVRENLPSGTHVLTPRATDKDEGLNAKLRFN 2529

Human   511 ILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLD 575
            :|..|:....|      :...|.|....:.:.|:|..:...::|:||.......|:..:.::|.|
  Fly  2530 LLGEHMHRFHI------DSETGEISTATTLDREETSVYHLTLMAQDSSITEPRASSVNLTISVSD 2588

Human   576 VNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDP 640
            ||||     :|...:.|..:.||.....|..|...||||.|.||:..:.|.| .|.|.|.|:|:.
  Fly  2589 VNDN-----IPKFDSTTYNVAVPERISKGEFVFGARALDLDDGENAVVHYTI-SGRDQHYFDINT 2647

Human   641 SSG------EIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKL-------------------- 679
            .:|      |::|.....:|:|  ..:|:...|.|:.:||:.|:|                    
  Fly  2648 KTGVVSTKLELKTKTKSHDDLT--YTIVISAMDQGEQSLSSKAELTVILRPPELFPTFAYMANSH 2710

Human   680 -----------IIRSVSGSLPE----GVPR------VNGEQHHWDMSLPLI--------VTLSTI 715
                       :|..||.:.|:    |..|      :.|:....|.:..|:        ..|:.:
  Fly  2711 FAMSEDVRPGKMITKVSATSPKKGLVGKIRYAIAGGIMGDSLRVDPNSGLLSVGQDGLDYELTHL 2775

Human   716 SIILLAA------------MITIAVKCKRENKEIR---TYNCRI-AEYSHPQL----------GG 754
            ..|.:.|            :||:.|....:|..:.   .||..: .|.|.|||          .|
  Fly  2776 YEIWIEAADGDTPSLRSVTLITLNVTDANDNAPVMEQLIYNAEVLEEESPPQLIAVVKASDRDSG 2840

Human   755 GKGKKKKINKNDI---------------MLVQSE-------VEERNAMNVMNVVSSPSLA----- 792
            ..|......:||.               |.:..|       |.|.....|.::..:.|:.     
  Fly  2841 DNGNVIYRLQNDFDGTFEITESGEIYTRMRLDREEIGDYAFVVEAVDQGVPHMTGTASVLLHLLD 2905

Human   793 --TSPMYFDYQTRL---------------------------------PLSSPRSEVMYLKPASNN 822
              .:|..|   |||                                 ..|....|...::|.|.|
  Fly  2906 KNDNPPKF---TRLFSLNVTENAEIGSFVIRVTSSDLDLGANANASYSFSENPGEKFRIEPQSGN 2967

Human   823 LTVPQGHAGCHTS-------FTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFK 880
            :|| .||......       ....|...:|||.|.....|.||.|          :|..|..:|.
  Fly  2968 ITV-AGHLDREQQDEYILKVVASDGAWRAETPITITIQDQNDNAP----------EFEHSFYSFS 3021

Human   881 DPER-----------ASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEP 934
            .||.           |:.||....:|..:.|.|..:.....|.:..|....|....|.....:.|
  Fly  3022 FPELQQSIALVGQIIATDRDKQGPNSVISYSLQQPSPMFSIDPATGEVFSKKAVRFKHSQYVRSP 3086

Human   935 EE----CVNCTD--------ECRVL-----GHSDRCWMPQFPAANQAENADYRTNLFVPTVEANV 982
            |.    .|..||        ||.|.     .|::   .|:|      |.|:|    ..|..:..|
  Fly  3087 ENMYALTVLATDNGKPPLYSECLVNINIVDAHNN---PPKF------EQAEY----LAPLPQDAV 3138

Human   983 ETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKR-----ALSPLLQEVPSA------- 1035
            ..:....|:...|:   ..|.::.:::::..|:.......|     .|...:|..|:.       
  Fly  3139 RGQRIVRVHANDKQ---DLGTNEMDYSLMTFNLSSIFSVGRHDGWITLVKPIQVPPNTRYELVVR 3200

Human  1036 --------SSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLSPSKQPRDPPFM- 1091
                    .|..|:..|   ..|..::|            :.::.....|.:.|..:|.....: 
  Fly  3201 ATDRGVPPQSDETRVVI---VVTGENMD------------TPRFSVNSYQVIVPENEPVGSTILT 3250

Human  1092 --ASDQ------MARVF---ADVHSRASRDSSEMGAVL-EQLD-------HPN---RDLGRESVD 1134
              |:|.      |.|..   .:.....|.|....|.|: :|||       |.|   :|||...:.
  Fly  3251 VGATDDDTGPNGMLRYSISGGNERQDFSVDERTGGIVIQQQLDYDLIQEYHLNITVQDLGYHPLS 3315

Human  1135 AEEVVREIDKLLQDCRGNDPV 1155
            :   |..:..:|.|...|.||
  Fly  3316 S---VAMLTIILTDVNDNPPV 3333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PCDH17NP_001035519.1 Cadherin_2 21..112 CDD:462413 23/100 (23%)
Cadherin_repeat 141..239 CDD:206637 38/237 (16%)
Cell attachment site. /evidence=ECO:0000255 186..188 1/128 (1%)
Cadherin_repeat 247..347 CDD:206637 36/100 (36%)
Cadherin_repeat 361..468 CDD:206637 31/115 (27%)
Cadherin_repeat 477..579 CDD:206637 25/101 (25%)
Cadherin_repeat 594..682 CDD:206637 30/124 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 858..909 13/61 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1108..1132 12/34 (35%)
ftNP_477497.1 Cadherin_repeat 71..152 CDD:206637
Cadherin_repeat 163..266 CDD:206637
Cadherin_repeat 275..378 CDD:206637
Cadherin_repeat 393..490 CDD:206637
Cadherin_repeat 498..594 CDD:206637
Cadherin_repeat 603..704 CDD:206637
Cadherin_repeat 735..814 CDD:206637
Cadherin 843..>907 CDD:394985
Cadherin 950..1026 CDD:394985
Cadherin_repeat 1053..1149 CDD:206637
Cadherin_repeat 1157..1274 CDD:206637
Cadherin_repeat 1282..1380 CDD:206637
Cadherin_repeat 1390..1485 CDD:206637
Cadherin_repeat 1497..1597 CDD:206637
Cadherin_repeat 1621..1699 CDD:206637
Cadherin_repeat 1720..1818 CDD:206637
Cadherin_repeat 1827..1918 CDD:206637
Cadherin_repeat 1926..2023 CDD:206637 26/116 (22%)
Cadherin_repeat 2031..2162 CDD:206637 18/130 (14%)
Cadherin_repeat 2172..2274 CDD:206637 20/101 (20%)
Cadherin_repeat 2282..2380 CDD:206637 36/100 (36%)
Cadherin_repeat 2388..2487 CDD:206637 31/121 (26%)
Cadherin_repeat 2495..2592 CDD:206637 25/102 (25%)
Cadherin_repeat 2600..2694 CDD:206637 31/96 (32%)
Cadherin_repeat 2710..2806 CDD:206637 15/95 (16%)
Cadherin_repeat 2814..2909 CDD:206637 17/94 (18%)
Cadherin_repeat 2917..3009 CDD:206637 15/92 (16%)
Cadherin 3018..3114 CDD:394985 21/95 (22%)
Cadherin 3129..3220 CDD:394985 14/100 (14%)
Cadherin_repeat 3233..3330 CDD:206637 22/99 (22%)
Cadherin_repeat 3338..3434 CDD:206637
Cadherin_repeat 3443..3541 CDD:206637
Cadherin_repeat 3550..3647 CDD:206637
Cadherin_repeat 3657..3753 CDD:206637
EGF 4017..4047 CDD:394967
EGF_CA 4056..4090 CDD:238011
EGF_CA 4094..4128 CDD:238011
Laminin_G_1 4156..4306 CDD:395008
LamG 4428..4543 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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