DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF115 and CG6923

DIOPT Version :9

Sequence 1:	NP_055270.1	Gene:	RNF115 / 27246	HGNCID:	18154	Length:	304	Species:	Homo sapiens
Sequence 2:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	212	Identity:	46/212 - (21%)
Similarity:	68/212 - (32%)	Gaps:	68/212 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    88 RPFLSSSPLDQDNRANERGHQTHTDFWGARPPRLPLGRRYRSRGS------SRPDRSPAIEGILQ 146
            :|....||....:...:|....|.......|..|.:|....|.||      |||:|...:|.|.:
  Fly  1100 QPQAQQSPPVMQHMQRQRAIHHHMFHHHYSPLHLEIGLAPLSLGSRILIAPSRPNRGATLETIER 1164

Human   147 HIFAGFFANSAIPGSPHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITS 211
            :..            ||.:.                            ::........|.||
  Fly  1165 NTL------------PHKYR----------------------------RVRRPSETDEDAEK--- 1186

Human   212 LPTVTVTQEQVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLN--- 273
                            |.:|...:.:|.|||:|||.|.||:.|:..||..:..||:||..:.
  Fly  1187 ----------------CAICLNLFEIENEVRRLPCMHLFHTDCVDQWLVTNKHCPICRVDIETHM 1235

Human   274 GEDSTRQSQSTEASASN 290
            ..|:...|.|....|:|
  Fly  1236 PNDALPPSSSGVPDAAN 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF115	NP_055270.1	zinc_ribbon_9	19..49	CDD:316857
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..138		12/48 (25%)
		RING-H2_RNF115	226..272	CDD:319714	19/45 (42%)
		RING-H2 finger (C3H2C3-type)	228..268	CDD:319714	17/39 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..304		5/22 (23%)
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	19/61 (31%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	17/40 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249953at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010