DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHMP2A and Vps2

DIOPT Version :9

Sequence 1:	XP_005258803.1	Gene:	CHMP2A / 27243	HGNCID:	30216	Length:	265	Species:	Homo sapiens
Sequence 2:	NP_651455.1	Gene:	Vps2 / 43164	FlyBaseID:	FBgn0039402	Length:	256	Species:	Drosophila melanogaster

Alignment Length:	299	Identity:	168/299 - (56%)
Similarity:	200/299 - (66%)	Gaps:	77/299 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAKD 65
            ||.|||::.:|:|:||:||||||:|||:|||||.|:|.||||||||||||||:||||||:|||||
  Fly     1 MDWLFGKKISPDEMLRKNQRALNKAMRDLDRERMKMEQQEKKIIADIKKMAKEGQMDAVKIMAKD 65

Human    66 LVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMMEFE 130
            |||||||.:||:||:|||||||||||||||.|:||||||||||||..|||||.|||||||:.:||
  Fly    66 LVRTRRYAKKFMLMKANIQAVSLKIQTLKSQNTMAQAMKGVTKAMQNMNRQLNLPQIQKILQDFE 130

Human   131 RQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSSECSKSWTPFPTQGP 195
            :|:|:|||||||:||||||||.||.||||:|||||||||||||.|.::|
  Fly   131 KQSEMMDMKEEMINDAIDDAMEDEGDEEETDAVVSQVLDELGLQLGEQL---------------- 179

Human   196 ATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVA--AGGKKAEA--------------- 243
                                       .||||..||||:|  ||.:||:|
  Fly   180 ---------------------------GDLPSASGSLSIAGGAGAQKAQAVAAGGVGGGGAAGGG 217

Human   244 -----------------AASALADADADLEERLKNLRRD 265
                             |:|.::||||||:.||..||:|
  Fly   218 GASGGGAGGPGAPGGSGASSPMSDADADLQARLDKLRKD 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHMP2A	XP_005258803.1	Snf7	17..181	CDD:281366	132/163 (81%)
Vps2	NP_651455.1	Snf7	17..185	CDD:281366	135/210 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140744
Domainoid	1	1.000	266	1.000	Domainoid score	I1895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6382
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2608
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53529
OrthoDB	1	1.010	-	-		D1254120at2759
OrthoFinder	1	1.000	-	-		FOG0005101
OrthoInspector	1	1.000	-	-		oto90524
orthoMCL	1	0.900	-	-		OOG6_102450
Panther	1	1.100	-	-	LDO	PTHR10476
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R316
SonicParanoid	1	1.000	-	-		X3622
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.900