Protein Alignment GPR162 and mAChR-B

DIOPT Version :9

• Sequence 1: NP_062832.1
• Gene: GPR162 / 27239
• HGNCID: 16693
• Length: 588
• Species: Homo sapiens
• Sequence 2: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Alignment Length: 691
• Identity: 129/691 - (18%)
• Similarity: 234/691 - (33%)
• Gaps: 203/691 - (29%)

Human    17 ALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASS 81
            |:....|.:|.:..|..::|:....:...:|....:..||.|.:|:..|.:..:.:..|:    .
  Fly   137 AICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLK----G 197

Human    82 DYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSF 146
            .:|....:|.:::|..||:.|.:.:||..::..|...|:....||....:.:.::.|...|::..
  Fly   198 YWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPA 262

Human   147 ILSTLPSIGW-HNNGERYYARG-C--QFIVSKIGLGFGVCFSLLLLGG------IVMGLVCVAIT 201
            :|..:...|| |..|:|....| |  ||:...|       |:..|:.|      ||:.::...|
  Fly   263 LLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPI-------FNTALIIGYYWTTLIVLFVLYAGI- 319

Human   202 FYQTLWARPRRARQARR--------VGGGGGTKAGGPGALGTRPAFEVPAIVVEDARGKRRSSLD 258
             |:|.:...:|:...:|        ..|.....||....:|          |:|:...|.:..|.
  Fly   320 -YKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIG----------VIEEKILKTKVELA 373

Human   259 GSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSF 323
            |.:        |:|.||...:...|:|            |..|.|   |||....:.:  :.|
  Fly   374 GDQ--------TDLDSACTTVIKRLSG------------SGQANP---LAVATEEVEK--MTP-- 411

Human   324 IWSCERYRADVRTVWEQC----VAIMSEE---------DGDDDGGCDD----YAEGRVCKVR--- 368
                |:.||....:.|:.    .|:.:|:         |.|::...:.    ..:.::..:|
  Fly   412 ----EQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRS 472

Human   369 -----FDANGA----TGPGS--RDPAQVKLLPGRHMLFPPLERVHYLQVPLSRRLSHDETNIF-- 420
                 |.|..|    .|.|:  :.....|.:...|. :...::.|:.|.||.|..|.:|....
  Fly   473 SIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQ-YHHHQQHHHNQSPLQRAQSKEEMRSLHH 536

Human   421 -STPREPGSFLH-----------KWSSSDDIRVLPAQSRA--LGGPPEYLG-------------- 457
             ...::|....|           |.:|...:..:....|.  |..||..|.
  Fly   537 HQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIE 601

Human   458 ----QRHR-------------------LEDEEDEEEAEGGGLASLR-----------QFLE--SG 486
                |.|:                   .:|..|.......|.:.|.           ::::  |.
  Fly   602 VPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSA 666

Human   487 VLGS-------------GGGPP---------RGPGFFREEITTFIDETPLPSPTASPGHSPRRPR 529
            :|.|             .|.||         |.|.  :..:...:.:||      |...||.:..
  Fly   667 MLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPP--KSNLNQSLSQTP------SQNQSPSQSL 723

Human   530 PLGLSPRRLSLGSPESRAVGLPLGLSAGRRCSLTGGEESAR 570
            .|.|:|..   ...:|:::...:.:......|.||.|:.|:
  Fly   724 SLNLNPNH---NQSQSQSIEEAVAIEKRLLVSYTGIEDFAK 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR162	NP_062832.1	7tm_1	34..>207	CDD:278431	41/182 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..474		9/67 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	511..550		9/38 (24%)
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	44/203 (22%)
		7tm_4	150..>336	CDD:304433	43/198 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910