DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR162 and gpr153

DIOPT Version :9

Sequence 1:	NP_062832.1	Gene:	GPR162 / 27239	HGNCID:	16693	Length:	588	Species:	Homo sapiens
Sequence 2:	XP_009302535.1	Gene:	gpr153 / 101883998	-ID:	-	Length:	641	Species:	Danio rerio

Alignment Length:	674	Identity:	290/674 - (43%)
Similarity:	373/674 - (55%)	Gaps:	168/674 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    13 LRSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRR 77
            :.:|||:||.|..:::|||||.|||:||||:|.||||.|:|.|||||||...:|:|.:.|:||||
Zfish     6 ISTNALAWLVCSGVSILANAWGILSVSAKQKKWKPLEFLICTLAGTHILNMGIPITMYCVIQLRR 70

Human    78 QASSDYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIW 142
            | .|:|:|||.:|||||||:|||.|.|||:|.||||||||||||||||||||.||||:|.|||||
Zfish    71 Q-HSNYEWNEGLCKVFVSTFYTLTLVTCFSVTSLSYHRMWMVRWPVNYRLSNTKKQAVHTVMGIW 134

Human   143 MVSFILSTLPSIGWHNNGERYYAR-GCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTL 206
            ||||||||||::|||:..||:|.: .|:|||::|||||||||.||:.|.:|||::|:.|..:||.
Zfish   135 MVSFILSTLPAVGWHDTTERFYTQDNCRFIVTEIGLGFGVCFLLLISGSVVMGVICIGIALFQTF 199

Human   207 WARPRRARQARRVGGGGGTKAGGPGALGTRPAFEVPAIVVEDARGKRRSSLDGSESAKTSLQVTN 271
                 ..:..:.|               .:..|.||.||||||:||||||:||||..|||||:|.
Zfish   200 -----SIQMGQNV---------------DKNKFNVPTIVVEDAQGKRRSSIDGSEPIKTSLQITY 244

Human   272 LVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADVRT 336
            |:|.|||:||.|||.|||||||.|||.|.:..||||.|||||:||::|||.|:|:|:||||||:.
Zfish   245 LISGIVFIYDFLTGFPILVVSFASLKFDRSYSWMVLCVLWCSIAQSILLPMFLWACDRYRADVKM 309

Human   337 VWEQCVAIMS----EEDGDDDGGCD---------DYAEG-------RVCKVRFDANGATGPGSRD 381
            |||:||||||    :|:...|||..         ||:..       |:.|..|......|...|:
Zfish   310 VWEKCVAIMSNDEVDEENSQDGGIHPDLIFDRPFDYSSAGDIMTVERIAKYEFSTLERGGYPLRE 374

Human   382 PAQVKLLPGRHMLFPPLERVHYLQVPLSRRLSHDETNIFSTPREPGSFLHKWSSSDDIRVLPAQS 446
            ..:              :::||||||.:||.|||||::::|.:.| |:||:|.|::||.
Zfish   375 LQE--------------DKMHYLQVPPTRRYSHDETDMWTTGQIP-SYLHRWGSTEDII------ 418

Human   447 RALGGPPEYLGQRH----------RLEDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPG-- 499
                |.|:|...||          |.|.....:......:.||:|.            ||...
Zfish   419 ----GIPQYNSPRHERRRSSPASYREESHPHRKRRRSEDMHSLKQI------------PRVERYE 467

Human   500 -----FFREEITTFIDETPLPSPTASP-------------------------GHSPRRPRPLGL- 533
                 |.|:|:..|||||||.||..||                         .|..|.|:.|..
Zfish   468 DNFKCFSRDEVINFIDETPLASPMRSPRRASAISLIPESFQQHIVLLPHFPLTHFEREPQVLRRC 532

Human   534 -----------SPRRLSLGSPESRAVG---------------------LPLGLSAGRRC--SLTG 564
                       :||:...||    |.|                     :|||...|.:.  |:..
Zfish   533 SGAMISEIPQDTPRKAKDGS----AAGEGSVVKGCLEHRHDAKNAPELVPLGARTGDQSSPSIRT 593

Human   565 GEESARAW--------GGSWGPGN 580
            |:.:|.||        |.|.|..|
Zfish   594 GQVNASAWVDHKHLSKGESKGSTN 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR162	NP_062832.1	7tm_1	34..>207	CDD:278431	118/173 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..474		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..550		18/96 (19%)
gpr153	XP_009302535.1	7tm_1	28..>191	CDD:278431	114/163 (70%)
gpr153	XP_009302535.1	LNP1	428..>511	CDD:292061	22/94 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D152625at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16518
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020