DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddx24 and CG9143

DIOPT Version :9

Sequence 1:	NP_001152974.1	Gene:	Ddx24 / 27225	MGIID:	1351337	Length:	903	Species:	Mus musculus
Sequence 2:	NP_611467.1	Gene:	CG9143 / 37296	FlyBaseID:	FBgn0034496	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	888	Identity:	332/888 - (37%)
Similarity:	484/888 - (54%)	Gaps:	130/888 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    50 KETNSKPKLASRGTFQRKGIKIVGKWKQVTIDPNLFAD--GQMDDLVCFEELTDY--RLVK---- 106
            |:..:||....:|..:...:.....|::|.|..::.:|  |..:.|:..|.|.||  .|||
  Fly     5 KQKTAKPPKLLKGAAKEPALSKAENWQKVKIKGHVISDDGGGFEGLIGLEVLKDYDASLVKSSQK 69

Mouse   107 -----NPSRLFSSEETKKRKAQAVSEEEEEEEGQSSSPKK---KIKL-----KKQRDAARAAEGA 158
                 ||.|    |...|:|.:.||:.:|||..:|||..:   ::.:     ||.|.|.|.|:..
  Fly    70 RTTSRNPDR----ERKLKKKKRKVSKGDEEESSESSSESESEDEVAVAARTSKKARLAERHAQKM 130

Mouse   159 AAQNEYEVKASE----PEAQGEVTACSDQKVGGAKSESLAQAAP-----RKKKNKGKKKLDTFQS 214
            ....|...|..|    .:::|:....|::......::..|...|     .::..|.:...|..:|
  Fly   131 QKLREKREKRKELRKQKKSKGKENDNSEESSDEHAADRFALLRPPPSDDEEEVVKAEDSADQQES 195

Mouse   215 TSPKLPKKSK-KTWMAEVHDQKADVSAWRDLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKL 278
            |..:.|:... .|..||      |:|||..|.||.::||||...||..||.||||||..||..|.
  Fly   196 TDEEAPELVPISTGEAE------DMSAWNGLGVPASILRALGEQGFKTPTQIQALTLPAAIHGKK 254

Mouse   279 DILGAAETGSGKTLAFAIPMIHSVLQWHKMKAPPIPRSTGMPPREMRFGATAHLGSPCKDRTESG 343
            ||||||||||||||||.|||:..:::              :..|.:|.|..       |.....|
  Fly   255 DILGAAETGSGKTLAFGIPMLAGIME--------------LKQRNIRSGIR-------KAPKVKG 298

Mouse   344 VLPEEARIETEAQPSDSGVQATPETSASASAQTLLVCDDDAGEGPSSLEEKPVPKQNEDGEEKFD 408
            ..||.|..|.|..|       .||             :.|...|.|              :|:.|
  Fly   299 QQPEPAADEHELTP-------PPE-------------ELDHVSGAS--------------DEESD 329

Mouse   409 AEQAGKLKQELCDQIAIYKVHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMST 473
            ||:..:..|              .||.|||||||||||:||:.|:.|.||:|||..|.:.||::.
  Fly   330 AEEQAQRVQ--------------TPLYGLVLTPTRELAVQVKNHLVAAAKYTGIRVAAIFGGLAV 380

Mouse   474 QKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEML 538
            .||:|:|.:.|:||:|||||||||..:.:.||..:..:..|||||.|||||||||.||..||::|
  Fly   381 AKQERVLRQCPDIVVATPGRLWELYAQGNRHLGKIEDVSFLVIDETDRMVEKGHFEELRSLLKVL 445

Mouse   539 N-DSQYNPSRQTLVFSATLTLVHQAPARILHKKHVKKMDK------TDKLDLLMQKVGMRGKPKV 596
            | |.|....||..|:||||||||..|.. :.|::|.|..|      ..|::.|::::|: .:||:
  Fly   446 NSDEQKKHQRQNFVYSATLTLVHDLPDH-MQKRNVGKRPKFVKQTVDQKIESLIEELGI-SQPKI 508

Mouse   597 IDLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQYPGRSLVFANSISCIKRLSGLLKVLDVMPL 661
            :|:|.::.|.:||||:::.|..|.||.:||||:.::|||::||.|||.|:|||:.|..:||..||
  Fly   509 VDITSSQQTAQTLTESRLLCPIDHKDYHLYYFIQRHPGRTIVFCNSIDCVKRLATLFGLLDCNPL 573

Mouse   662 TLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTAR 726
            .|||.|.|||||:|||:|......:|:||||||||||||.|:||||||||||||.|:||||||||
  Fly   574 PLHANMIQKQRLKNLERFRDSPTGLLIATDVAARGLDIPNVEHVIHYQVPRTSENYVHRSGRTAR 638

Mouse   727 AASEGLSLMLIGPEDVINFKKIYKTLQKDEDIPLFPVQSKYMDVVKERIRLARQIEKAEYRNFQA 791
            |...|:::|.:.|.:|.::.|:||||::.||:||||:..::|..|:||:.|||.::|.|.:..:.
  Fly   639 ANKHGITVMFMEPGEVKSYVKLYKTLERTEDLPLFPILERFMGAVRERVNLARDLDKEELKLKRV 703

Mouse   792 CLHNSWIEQAAAALEIELEEEMYKGGKADQQE-----ERRRQK-QMKMLKQELRHLLSQPLFQEN 850
            .....|:::.|..:::.::....:.| :||.|     ||||.: :::.::.:|..||:||:|...
  Fly   704 QSERGWMKKHAEEMDMIIDGYNDESG-SDQDEDPFVIERRRNRLRVETVRAQLNALLAQPIFPRG 767

Mouse   851 LKTRYPTQSGRPPQPVLASRNIESALSCLSRQKRRRKKPKEPR 893
            ...:||......    ||:.:.:||:..:......:|:.|:.|
  Fly   768 FSFKYPNSEAAQ----LATSHTQSAVETMKAAIEDQKQAKKDR 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddx24	NP_001152974.1	SrmB	238..787	CDD:223587	254/555 (46%)
		P-loop_NTPase	241..557	CDD:304359	132/316 (42%)
		Helicase_C	619..727	CDD:278689	71/107 (66%)
CG9143	NP_611467.1	BLVR	<125..191	CDD:283923	10/65 (15%)
		SrmB	201..747	CDD:223587	269/623 (43%)
		P-loop_NTPase	217..465	CDD:304359	132/316 (42%)
		HELICc	531..648	CDD:238034	74/116 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839436
Domainoid	1	1.000	178	1.000	Domainoid score	I3548
eggNOG	1	0.900	-	-		E2759_KOG0347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10702
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1374
Isobase	1	0.950	-	0	Normalized mean entropy	S2436
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	1	1.000	-	-		FOG0004383
OrthoInspector	1	1.000	-	-		oto93870
orthoMCL	1	0.900	-	-		OOG6_102605
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R679
SonicParanoid	1	1.000	-	-		X3667
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750