DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atp1a4 and Atpalpha

DIOPT Version :9

Sequence 1:	NP_038762.1	Gene:	Atp1a4 / 27222	MGIID:	1351335	Length:	1032	Species:	Mus musculus
Sequence 2:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster

Alignment Length:	1005	Identity:	717/1005 - (71%)
Similarity:	843/1005 - (83%)	Gaps:	4/1005 - (0%)

- Green bases have known domain annotations that are detailed below.

Mouse    30 RQPKMKRRKKDLEELKKEVVMDDHKLTLDELSAKYSVDLTKGLSILEAQDILFQNGPNVLTPPPT 94
            :.|....:|::|::||:|:.:|.||::.:||..::......|||..:|::.|.::|||.||||..
  Fly    39 KMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQ 103

Mouse    95 TPEWVKFCRQLFGGFSLLLWTGACLCFLAYGIHVNYYKENANKDNLYLGIVLSAVVIITGCFSYY 159
            ||||||||:.|||||::|||.||.|||:||.|..:..:|.|: ||||||||||||||:||.||||
  Fly   104 TPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPAD-DNLYLGIVLSAVVIVTGIFSYY 167

Mouse   160 QEAKSSKIMESFKNMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGDQIPADIRVISAQGCKVD 224
            ||:|||||||||||||||.|.|||:|||:.:...|:||||:||||.||:||||||:|.|:..|||
  Fly   168 QESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVD 232

Mouse   225 NSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGTARGIVIATGDYTVMGRIASLTSGLQM 289
            |||||||||||||..:.||||||||:|:.|||||.|||||:|:||:.||:|||||||.|.|||..
  Fly   233 NSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDT 297

Mouse   290 GKTPIATEIEHFIHLITAVAVFLGVSFFWLSIILGYTWLDAVIFLIGIIVANVPEGLLATVTVCL 354
            |:||||.||.|||||||.|||||||:||.::.||||.||||||||||||||||||||||||||||
  Fly   298 GETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCL 362

Mouse   355 TLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEEQTTG 419
            ||||||||.|||||||||||||||||||||||||||||||||||||:|||..:.||||:|:| :|
  Fly   363 TLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQ-SG 426

Mouse   420 KTFPKSSDTWFYLARIAGLCNRADFKPHQESVPIAKRATTGDASESALLKFIEQSYNPVSEMRQK 484
            ..:.::|..:..|:|||.|||||:||..|:.|||.|:..:|||||:||||.:|.:...|..:|::
  Fly   427 VQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKR 491

Mouse   485 NPKVAEIPFNSTNKYQMSIHLLED-NSEAHVLLMKGAPERIFDFCSSFLLNGQEYPMDEEMKMDF 548
            |.|:||:|||||||||:|||..|| |...::|:||||||||.:.||:..:||:|..:|||||..|
  Fly   492 NKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAF 556

Mouse   549 QNAYIELGGLGERVLGFCFLNLPSN-FSKGFQFNTDELNFPMENLCFAGLISMIDPPRTAVPDAV 612
            .|||:|||||||||||||...|||: :..||:||||::|||::||.|.||:|||||||.||||||
  Fly   557 NNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAV 621

Mouse   613 SKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNDTAEDIAARLNIPISQVNNKSVKAIVVHGS 677
            :||||||||||||||||||||||||||||||||||:|.||||.|||||:|:||.:..||.||||:
  Fly   622 AKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGA 686

Mouse   678 ELKDMESQQLDDILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIA 742
            ||:|:.|.|||:||:.:.|||||||||||||||||||||:|||||||||||||||||||||||:|
  Fly   687 ELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVA 751

Mouse   743 MGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIILSI 807
            |||.||||||||||||||||||||||||||||||||||||||||||||||||||:|||.||:..|
  Fly   752 MGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDI 816

Mouse   808 PLPLGTITILCIDLGTDMVPAISLAYESPESDIMKRLPRNPKTDNLVNNRLIGMAYGQIGMIQAL 872
            ||||||:||||||||||||||||||||..|:|||||.||:|..|.|||:|||.|||||||||||.
  Fly   817 PLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAA 881

Mouse   873 AGFFTYFVILAENGFKPLDLLGIRLYWDDTQLNDLEDSYGQQWTYEQRKVVEFTCQTAFFISIVI 937
            ||||.||||:|||||.|..|.|||..||...:|||.|||||:|||..||.:|:||.||||||||:
  Fly   882 AGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVV 946

Mouse   938 VQWADLIICKTRRNSLFKQGMKNKILIFGLLEETVLAAFLSYVPGMDVSLRMYPLKINWWFCALP 1002
            |||||||||||||||:|:|||:|..|.|||:.||||||||||.|||:..|||||||:.|||.|:|
  Fly   947 VQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIP 1011

Mouse  1003 YSVLIFVYDEIRKLIIRRRPGGWLEKETYY 1032
            :::.||:|||.|:..:||.||||||:||||
  Fly  1012 FALAIFIYDETRRFYLRRNPGGWLEQETYY 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp1a4	NP_038762.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		2/11 (18%)
		ATPase-IIC_X-K	36..1032	CDD:273445	714/997 (72%)
		Cation_ATPase_N	50..123	CDD:214842	38/72 (53%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	91..93		1/1 (100%)
		E1-E2_ATPase	144..375	CDD:278548	181/230 (79%)
		Cation_ATPase	438..530	CDD:289987	53/92 (58%)
		COG4087	<696..761	CDD:226572	61/64 (95%)
		Cation_ATPase_C	808..1017	CDD:279079	152/208 (73%)
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	714/997 (72%)
		Cation_ATPase_N	58..132	CDD:214842	38/73 (52%)
		E1-E2_ATPase	152..383	CDD:278548	181/230 (79%)
		Cation_ATPase	445..539	CDD:289987	54/93 (58%)
		COG4087	<695..770	CDD:226572	66/74 (89%)
		Cation_ATPase_C	817..1025	CDD:279079	152/207 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	333	1.000	Domainoid score	I1136
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm43230
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.780