Protein Alignment GPC3 and dlp

DIOPT Version :10

• Sequence 1: NP_001158089.1
• Gene: GPC3 / 2719
• HGNCID: 4451
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 678
• Identity: 142/678 - (20%)
• Similarity: 261/678 - (38%)
• Gaps: 128/678 - (18%)

Human     2 AGTVRTACLVV------AMLLSLDFPG--QAQPPPPPPDA----------------------TCH 36
            |....||.||:      .:||:...|.  ||...|.|..|                      .|.
  Fly    17 ATATTTARLVIFSSPLLLLLLTTHLPPTLQADNGPAPQVAALAAPNPAGGVAGSSIIDQFSPNCS 81

Human    37 QVRSFFQRLQPGLKWVPETPVPGSDLQVC-LPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMEL 100
            .|...||........:|:.|.....|:.| .|...|||:..||.:..:.:|..:|...:.....:
  Fly    82 AVTHIFQARGIDAIEIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQISRM 146

Human   101 KFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDIN--- 162
            ..::...|..|::.|..:::.::...|:||...|..:..:......:.|.::..|.....::
  Fly   147 SGILGSKATKFKDIFTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVDLLE 211

Human   163 -VDDMVNELFDSLFPVIYTQLMNPGLPDSALDIN--ECLRGARRDLKVFGNFPKLIMTQVSKSLQ 224
             :|...|.|:..:|.|:.||.        ..|.|  .|:....::||.||:.|..:..|:.:|..
  Fly   212 VMDKFFNTLYQKMFTVLNTQY--------TFDENYMRCVSEHMKELKPFGDVPDKLSVQIKRSFV 268

Human   225 VTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGV 289
            .||.:.|||....||.....:::.:.||...||:|.:|..|:| ...|||..||..|::||:...
  Fly   269 ATRTYGQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKG-YTEKPCTNYCVNVIKGCLHYQ 332

Human   290 VEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTETE------- 347
            .|.|..|..:.::::::...:...:::..|:..|...|.::|...|.:...:|....:
  Fly   333 HEFDSEWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKL 397

Human   348 KK-------------IWHFKYPIFFLCIGLDLQIGKLCAHSQQR------QYRSAYYPEDLFIDK 393
            ||             |.:.:.|:....:.:|..:.:.....::|      |..||...::..:.|
  Fly   398 KKMKRSISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGK 462

Human   394 -------------------KVLKVAHVE-----------------HEETLSSRRRELIQKLKSFI 422
                               |..:....:                 .|..|....|::.|::|.:.
  Fly   463 SGNGGGGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYK 527

Human   423 SFYSALPGYICSHSPVAEN---DTLCWNGQELVERYSQK-AARNGMKNQFNLHELKMKGPEPVVS 483
            .|:|.||..:||:..:|.:   |.:|||| ..::||... ...:|...:|..:....|    ..:
  Fly   528 KFWSNLPHSVCSNEDIASSSDVDGMCWNG-HTIDRYMHSITTEHGSNPEFTGNPASTK----QTA 587

Human   484 QIIDKLKHI-NQLLRTMSMPKGRVLDKNLDEE------GFESGDCGDDEDECIGGSGDGMIKVKN 541
            |:..:|.|: |.::...:...|:.::.:..||      |..||...:|:::...|||.|..:..:
  Fly   588 QMASQLSHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGSGSEDDEDDDEGSGLGPFEPSH 652

Human   542 QLRFLAELAYDLDVD---DAPGNSQQAT 566
            : ..:...:.|.|.|   ||.|.....|
  Fly   653 K-PDVERPSVDADNDDDEDAGGRGHMPT 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPC3	NP_001158089.1	Glypican	14..600	CDD:460084	137/660 (21%)
dlp	NP_524071.2	Glypican	79..619	CDD:460084	112/553 (20%)