Protein Alignment GPC3 and dally

DIOPT Version :9

• Sequence 1: NP_001158089.1
• Gene: GPC3 / 2719
• HGNCID: 4451
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_001246685.1
• Gene: dally / 39013
• FlyBaseID: FBgn0263930
• Length: 626
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 132/568 - (23%)
• Similarity: 220/568 - (38%)
• Gaps: 131/568 - (23%)

Human    35 CHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASME 99
            |..|:|:|:.:.     :..:........:|   |..||:...|.:.:..|....||||...:..
  Fly    69 CDAVKSYFESID-----IKSSGTYSEKGAIC---GGNCCNNATELELRDKAAGMFEQLLHHHTSS 125

Human   100 LKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYI-------- 156
            |:.::..||..||.....:.:.::|.|:::|...|..:.|.:...:.:.:|::..::
  Fly   126 LRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHLIYTSNYTN 190

Human   157 ---------LGS-DINVDDMVNELFDSLFPVIYTQLMN---PGLPDSALDINECLRGARRDLKVF 208
                     :|| ..|:::.|...|..||||.|.|:::   ..|.|...|...||:....::..|
  Fly   191 SNGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLHEDYVNCLQHNFDEMHPF 255

Human   209 GNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHL---KFSKDCGRMLTRMWYCSYCQG--- 267
            |:.|:.:.:.:.||:.::.:|:.||....||::..|.|   :.:..|...|.:|.||..|.|
  Fly   256 GDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLKMHYCPNCNGHHS 320

Human   268 --LMMVKPCGGYCNVVMQGC---MAGVVEIDKYWREYILSLEELVNGMYRIYD--MENVLLGLFS 325
              ....|.|.|||..||:||   .||:  :|..|...:.||..||. .:.:.|  :.||:..|.:
  Fly   321 SSRSETKLCYGYCKNVMRGCSAEYAGL--LDSPWSGVVDSLNNLVT-THILSDTGIINVIKHLQT 382

Human   326 TIHDSIQYVQKNAGKLTTTETEKKIWHFKYPIFFLCIGLDLQIGKLCAHSQQRQYRS-------- 382
            ...::|.....|.     .|.|||                  :.|.|.......|.|
  Fly   383 YFSEAIMAAMHNG-----PELEKK------------------VKKTCGTPSLTPYSSGEPDARPP 424

Human   383 --------AYYPED---LFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHS 436
                    |..|:.   ||:                     ..|.|.|   .||:.:....|...
  Fly   425 PHKNNVKWATDPDPGMVLFL---------------------STIDKSK---EFYTTIVDNFCDEQ 465

Human   437 PVAENDTLCWNGQELVERYSQKAARNGMKNQ-------FNLHELKMKGPEPVVSQIIDKL----K 490
            ..:.:|..||:|....: |:|.....|..:|       ||     .|.....:::::|||    |
  Fly   466 QHSRDDHSCWSGDRFGD-YTQLLINPGTDSQRYNPEVPFN-----AKAQTGKLNELVDKLFKIRK 524

Human   491 HINQLLRTMSMPKGRVLDKNLDE-EGFESGDCGDDEDECIG--GSGDG 535
            .|.....:.|:.....:..::.| .|...|..||||:|..|  |||||
  Fly   525 SIGAAAPSNSIQATHDIQNDMGEGSGGGEGQIGDDEEEYGGAHGSGDG 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPC3	NP_001158089.1	Glypican	14..600	CDD:279494	132/568 (23%)
dally	NP_001246685.1	Glypican	51..622	CDD:279494	132/568 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147853
Domainoid	1	1.000	186	1.000	Domainoid score	I3356
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1097767at2759
OrthoFinder	1	1.000	-	-		FOG0003365
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10822
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810