Protein Alignment DISC1 and Disc1

DIOPT Version :10

• Sequence 1: NP_001158009.1
• Gene: DISC1 / 27185
• HGNCID: 2888
• Length: 886
• Species: Homo sapiens
• Sequence 2: NP_783186.2
• Gene: Disc1 / 307940
• RGDID: 631359
• Length: 824
• Species: Rattus norvegicus
• Alignment Length: 908
• Identity: 465/908 - (51%)
• Similarity: 584/908 - (64%)
• Gaps: 108/908 - (11%)

Human     1 MPGGGPQGA----PAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPAV 61
            |.|.|.:||    |:...|.|  |  ||    |||...:||||.||||||||:..||||||||||
  Rat     1 MQGAGSRGAWIHSPSHCPGNG--H--GS----PPAVAPQRRRLTRRPGYMRSTASPGIGFLSPAV 57

Human    62 GTLFRFPGGVSGEESHHSESRARQCGLDSRG----LLVRSPVSKSAAAPTVTSV----------R 112
            |.......|::|:|.:.|:|:||||.||.|.    .||.:|..|.:..|.||||          |
  Rat    58 GMPRPISAGLTGQEFYPSQSKARQCSLDLRSHCQDSLVGNPFLKGSLGPAVTSVGHLHPAQGSMR 122

Human   113 GTSAHFGIQLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSL 177
            ....|.|:......|..:||:     |.:|.:|||.:.|||::|.:|.:.|.|.|:|.::....|
  Rat   123 ERMVHSGVHSGNDRRQSERLT-----GDSGCRQEFLSSDSSKSLASSLDVAWSKGSRGLKTVRPL 182

Human   178 PSAELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQSP 242
            .|.  :||      ||...|:.||....|||:|||||||||:||||||||||.||||||...|||
  Rat   183 VSP--ASN------GPVDIPSLPGFQDTFTSNFSFIRLSLGAAGERGEAEGCLPSREAEPLHQSP 239

Human   243 QEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPGSSSSLDP 307
            |||.|:.:..|.||.:||.| ..|||.|.....||||..|::.:||..|.|..|   ...||.|.
  Rat   240 QEMAAEGSGSDRPHGEPRHL-WTFSLHAAPGLVDLAQGTRSNRQPECGMVSSSD---AGFSSQDA 300

Human   308 SLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDK 372
            |.||...|...|..|||.|..|||:|||:|:|.||.||||:||.||.||||||||.|||:.|||
  Rat   301 SPAGGRSDQDGGWADAHGWHALLREWEPMLQDYLLSNRRQLEVTSLILKLQKLQEKAVEDGDYD- 364

Human   373 VETGFHYVGQAGLELLTSSNPPASASQSAGITAETLQQRLEDLEQEKISLHFQLPSRQPALSSFL 437
                                           .||||:||||||||||..|.:.|||:||||.|||
  Rat   365 -------------------------------MAETLRQRLEDLEQEKGRLPWALPSQQPALRSFL 398

Human   438 GHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSL-HVSITRRDWLLQEKQQLQKEI 501
            |:||.|..||| .||.|:|..||...||..:.|   .|||||| .:::||||||::||:||||||
  Rat   399 GYLATQTHAAL-HGAPQRAGSDDPEAPLEGQRR---TTAQDSLPGLAVTRRDWLMREKEQLQKEI 459

Human   502 EALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIP 566
            |||:||:.|||||:|:|.:|:|:||..|:|||||...||.|||.||||||||||.:||.||...|
  Rat   460 EALRARVSVLEAKEQRLSQELEDQEMLLRWQGCDQMALVAQLSPGQLQEVSKALGETLTSARWAP 524

Human   567 FHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGN 631
            |..|||||:|||:||.|||:|:::|:|.:||..||.||:|||::.|::|:|||||||||.|:||:
  Rat   525 FRVEPPETLRSLRERTKSLDLAVRELTEQVCSGEKLCSSLRKRLADLDTRLPALLEAKMLALSGS 589

Human   632 HFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSV 696
            .|.|||:|.|||.:::|||||||..|.:||.|||||.::||||||||.|.|:::..||.|::|.|
  Rat   590 CFSTAKELAEEIWAVSSEREGLEMFLGRLLALSSRNTRRLGSVKEDYLRCRQDLALQEAAHKTRV 654

Human   697 KENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQM----DDL 757
            |.||:|..|.|:.:|..|:||||.:||:||||||:||:|||::|||..|..||||:|:    :..
  Rat   655 KANTVKCTEVLEGQLSCCRCPLLERVWKADLEACQLLMQSLEIQEAGSSSHVEDEKQVHSTGEAA 719

Human   758 EGAAPPIPPRLHSEDKRKTPLKVLEEWKTHLIPSLHCAGGEQKEESYILSAELGEKCEDIGKKLL 822
            :.||..:|...|.|:: |:||                      :||:::.||:|:|||.||.:||
  Rat   720 QTAALAVPRTPHPEEE-KSPL----------------------QESHVVFAEVGDKCEAIGMRLL 761

Human   823 YLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQ 885
            :|||||..|:|.|||.|.|||:.||||||||||.|.|||||||||| .||:||..|||..||:
  Rat   762 HLEDQLLGAMHGHDEALFQSLQGELQMVKETLQTMFLQLQPAKEAG-GEASASYSTAGAQEAE 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DISC1	NP_001158009.1	PRK11281	382..>506	CDD:481316	64/124 (52%)
		CCDC158	<408..>810	CDD:464943	223/406 (55%)
Disc1	NP_783186.2	SMC_prok_B	<349..>621	CDD:274008	174/307 (57%)