DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGLEC8 and meis1

DIOPT Version :9

Sequence 1:	NP_055257.2	Gene:	SIGLEC8 / 27181	HGNCID:	10877	Length:	499	Species:	Homo sapiens
Sequence 2:	XP_002931792.1	Gene:	meis1 / 100488182	XenbaseID:	XB-GENE-479439	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	301	Identity:	57/301 - (18%)
Similarity:	85/301 - (28%)	Gaps:	136/301 - (45%)

- Green bases have known domain annotations that are detailed below.

Human    16 GMEG----DRQYGDGYLLQ-VQELVTVQEGLCVHVPCSFSYPQDGWT-----------------D 58
            ||:|    ...|||.:..: :|.:..:..|..:|   |..||....|                 |
Frog    13 GMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLH---SHQYPHTAHTNAMPPSMGSSVNDALKRD 74

Human    59 SDPVHGY-----------------------WFRAGD----------------RPYQDAPVATNNP 84
            .|.::|:                       ....||                :...:.|:.::||
Frog    75 KDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNP 139

Human    85 DRE---VQAETQGRFQLL-----GDIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNY 141
            :.:   :||....||.||     .::..|.|.                         .|.|.|..
Frog   140 ELDNLMIQAIQVLRFHLLELEKVHELCDNFCH-------------------------RYISCLKG 179

Human   142 KTKQLSVFVTALTHRPDILILGTLESG---HSRNLTCSVPWACKQGTPPMISWI-----GASVSS 198
            |             .|..|::...|.|   .|.::|.|.|...:.      ||.     .||..|
Frog   180 K-------------MPIDLVIEDREGGSKSDSEDMTRSAPLTDQP------SWSRDHDDTASTRS 225

Human   199 ---PGPT----TARSSVLTLTPKPQDHGTSLTCQVTLPGTG 232
               |||:    |:.|.     ....:.|..|...|..|.||
Frog   226 GGTPGPSSGGHTSHSG-----DNSSEQGDGLDNSVASPSTG 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC8	NP_055257.2	Ig	27..151	CDD:299845	27/188 (14%)
		Carbohydrate binding. /evidence=ECO:0000269\|PubMed:27357658, ECO:0007744\|PDB:2N7B	72..75		0/2 (0%)
		Carbohydrate binding. /evidence=ECO:0000269\|PubMed:27357658, ECO:0007744\|PDB:2N7B	134..138		1/3 (33%)
		Ig	171..229	CDD:299845	16/69 (23%)
		IG_like	269..344	CDD:214653
		IGc2	275..335	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..443
		ITIM motif	445..450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..470
		SLAM-like motif	468..473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..499
meis1	XP_002931792.1	Meis_PKNOX_N	108..192	CDD:374576	19/121 (16%)
meis1	XP_002931792.1	Homeobox_KN	290..329	CDD:368670
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I35468
eggNOG	1	0.900	-	-		E1_2CYFK
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm54708
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.860