DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC8 and si:ch73-380l3.2

DIOPT Version :9

Sequence 1:	NP_055257.2	Gene:	SIGLEC8 / 27181	HGNCID:	10877	Length:	499	Species:	Homo sapiens
Sequence 2:	NP_001348166.1	Gene:	si:ch73-380l3.2 / 100003913	ZFINID:	ZDB-GENE-080303-1	Length:	266	Species:	Danio rerio

Alignment Length:	223	Identity:	57/223 - (25%)
Similarity:	93/223 - (41%)	Gaps:	35/223 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    25 DGYLLQVQELVTVQEGLCVHVPCSFSYP-QDGWTDSDPVHGYWFRA---------GDRPYQDAPV 79
            |.:.:.|:..:......||.:||:|:|| ......|..:.|.|.:.         ||:..
Zfish    22 DVWKVDVEHKMKALVSSCVVLPCNFTYPVHQQQQPSYRIRGIWHKMNKWDDIIFYGDKTL----- 81

Human    80 ATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTK 144
                    |:...:||.:|:|.:.|.:|||.|.:.:..|.|.|.||:|   ::.:.|.:.::...
Zfish    82 --------VEDNFKGRTRLIGSLGSFNCSLEIDEVKNTDNGPYCFRVE---LETAPKDKYSFVDN 135

Human   145 QLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISW--IGASVSS-----PGPT 202
            .:|:.......:|.:....::..|......|||...|.. ..|..||  .|..:||     .|..
Zfish   136 CVSITTIEEAPKPMLEAETSVLEGEPAIFKCSVRHTCPT-YQPSFSWNRAGKIISSYNDLGHGNW 199

Human   203 TARSSVLTLTPKPQDHGTSLTCQVTLPG 230
            .| .|:||.||..:|:.||:.|.|...|
Zfish   200 EA-ESLLTFTPTKEDNYTSIECTVKYHG 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC8	NP_055257.2	Ig	27..151	CDD:299845	31/133 (23%)
		Carbohydrate binding. /evidence=ECO:0000269\|PubMed:27357658, ECO:0007744\|PDB:2N7B	72..75		0/2 (0%)
		Carbohydrate binding. /evidence=ECO:0000269\|PubMed:27357658, ECO:0007744\|PDB:2N7B	134..138		1/3 (33%)
		Ig	171..229	CDD:299845	22/64 (34%)
		IG_like	269..344	CDD:214653
		IGc2	275..335	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..443
		ITIM motif	445..450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..470
		SLAM-like motif	468..473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..499
si:ch73-380l3.2	NP_001348166.1	Ig	24..141	CDD:325142	31/132 (23%)
si:ch73-380l3.2	NP_001348166.1	Ig	148..226	CDD:325142	24/79 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I12412
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.060