Protein Alignment SIGLEC9 and Siglec8

DIOPT Version :10

• Sequence 1: NP_001185487.1
• Gene: SIGLEC9 / 27180
• HGNCID: 10878
• Length: 479
• Species: Homo sapiens
• Sequence 2: NP_001419063.1
• Gene: Siglec8 / 292846
• RGDID: 1563073
• Length: 457
• Species: Rattus norvegicus
• Alignment Length: 405
• Identity: 225/405 - (55%)
• Similarity: 281/405 - (69%)
• Gaps: 15/405 - (3%)

Human     2 LLLLLPLLWGRERAEGQTSKL----LTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWF 62
            :||||.||||.:..||....|    |.::..|.|||||||.|||:||||.. |......|:||||
  Rat     1 MLLLLLLLWGIKGVEGGAVALKGYTLNVERKVVVQEGLCVLVPCNFSYPKF-WQTDSSPVYGYWF 64

Human    63 REGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIK 127
            |:.||||.|||||||||.|...|.|:.||.|.||....:|:|:||:.::.|||.||||:|:|..|
  Rat    65 RKKANTDIDAPVATNNPKRPAQERTQHRFFLPGDQQKNDCSLNIREIKKKDAGTYFFRLERGKTK 129

Human   128 WNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPST 192
            :||..:.::::|||||:...|| |.|||:|.|.||||||||.||:..||:.||.|||||||..:|
  Rat   130 YNYLWNMMTLDVTALTNTLRIL-PETLEAGHPSNLTCSVPWDCEKRAPPVFSWNGTSVSPLSTNT 193

Human   193 TRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNG 257
            |.|||||:|||||||||:||||||.||..|||..|:.|||||.|:|||:||:||..:|||:|.||
  Rat   194 TGSSVLTIIPQPQDHGTNLTCQVTLPGTDVTTRMTIRLNVSYAPKNLTVTVYQGADSVSTILKNG 258

Human   258 SSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRA 322
            |||.:.|||||||:|   :.||.|||.||.||..|||||.:.|.||:|||..:||:....:||:|
  Rat   259 SSLQISEGQSLRLIC---SADSYPPANLSWSWGNLTLCPPKLSKPGLLELFPMHLKHEGVYTCQA 320

Human   323 QNPLGSQQVYLNVSLQSKAT-SGVTQGVVGGAGATALVFLSFCVIFVVVRSCRKKSARPAAGVGD 386
            |:.||||.:.||:|.|..|| |.:..|.:..:|.|||:|||||:|.:.|||||:|.||.|...
  Rat   321 QHALGSQYISLNLSPQRSATLSEMMMGTLMDSGVTALLFLSFCIILLAVRSCRRKPARTAVVA-- 383

Human   387 TGIEDANAVRGSASQ 401
               ...||::.|.||
  Rat   384 ---PHPNALKVSVSQ 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC9	NP_001185487.1	IgV_CD33	23..140	CDD:409377	60/116 (52%)
		FR1	23..45	CDD:409377	13/21 (62%)
		Ig strand A'	28..32	CDD:409377	1/3 (33%)
		Ig strand B	34..45	CDD:409377	8/10 (80%)
		CDR1	46..54	CDD:409377	2/7 (29%)
		FR2	57..64	CDD:409377	5/6 (83%)
		Ig strand C	57..64	CDD:409377	5/6 (83%)
		CDR2	65..88	CDD:409377	15/22 (68%)
		Ig strand C'	75..78	CDD:409377	2/2 (100%)
		FR3	89..122	CDD:409377	16/32 (50%)
		Ig strand D	90..94	CDD:409377	2/3 (67%)
		Ig strand E	100..108	CDD:409377	3/7 (43%)
		Ig strand F	115..123	CDD:409377	5/7 (71%)
		CDR3	123..126	CDD:409377	1/2 (50%)
		FR4	127..140	CDD:409377	3/12 (25%)
		Ig strand G	127..140	CDD:409377	3/12 (25%)
		Ig	146..231	CDD:472250	57/84 (68%)
		Ig strand B	160..164	CDD:409353	2/3 (67%)
		Ig strand C	177..181	CDD:409353	1/3 (33%)
		Ig strand E	196..200	CDD:409353	3/3 (100%)
		Ig strand F	210..215	CDD:409353	3/4 (75%)
		Ig strand G	225..228	CDD:409353	0/2 (0%)
		Ig	257..339	CDD:472250	45/81 (56%)
		Ig strand B	268..272	CDD:409353	3/3 (100%)
		Ig strand C	284..288	CDD:409353	2/3 (67%)
		Ig strand E	306..310	CDD:409353	2/3 (67%)
		Ig strand F	317..322	CDD:409353	2/4 (50%)
		Ig strand G	332..335	CDD:409353	1/2 (50%)
Siglec8	NP_001419063.1	Ig	24..142	CDD:472250	60/118 (51%)
		Ig strand B	40..44	CDD:409353	2/3 (67%)
		Ig strand C	60..64	CDD:409353	2/3 (67%)
		Ig strand E	104..108	CDD:409353	2/3 (67%)
		Ig strand F	118..123	CDD:409353	3/4 (75%)
		Ig strand G	131..137	CDD:409353	2/5 (40%)
		Ig	152..232	CDD:472250	55/79 (70%)
		Ig strand B	161..165	CDD:409353	2/3 (67%)
		Ig strand C	178..182	CDD:409353	1/3 (33%)
		Ig strand E	197..201	CDD:409353	3/3 (100%)
		Ig strand F	211..216	CDD:409353	3/4 (75%)
		Ig strand G	226..229	CDD:409353	0/2 (0%)
		Ig	258..336	CDD:472250	45/80 (56%)
		Ig strand B	269..273	CDD:409353	3/3 (100%)
		Ig strand C	282..286	CDD:409353	2/3 (67%)
		Ig strand E	304..308	CDD:409353	2/3 (67%)
		Ig strand F	315..320	CDD:409353	2/4 (50%)
		Ig strand G	330..333	CDD:409353	1/2 (50%)