DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TUBG2 and alphaTub85E

DIOPT Version :9

Sequence 1:	XP_024306462.1	Gene:	TUBG2 / 27175	HGNCID:	12419	Length:	596	Species:	Homo sapiens
Sequence 2:	NP_524297.1	Gene:	alphaTub85E / 41183	FlyBaseID:	FBgn0003886	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	109/312 - (34%)
Similarity:	168/312 - (53%)	Gaps:	26/312 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     3 REIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFAT--EGTDRKDVFFYQADDEHYIPRAV 65
            ||.|::.:||.|.|||...|:..|.||||.|:|.:....|  .|.|....||.:.....::||||
  Fly     2 RECISVHIGQAGVQIGNACWELYCLEHGIQPDGHMPSDKTVGGGDDSFSTFFSETGAGKHVPRAV 66

Human    66 LLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASG-FSQGEKIHEDIFDIIDREADGS 129
            .:||||.|:..:....|.:|::||.:...:.  .|.||:|.| ::.|::|.:.:.|.|.:.||..
  Fly    67 FVDLEPTVVDEVRTGTYRQLFHPEQLITGKE--DAANNYARGHYTIGKEIVDVVLDRIRKLADQC 129

Human   130 DSLELQNSSRVIKGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPYQDEMSDVVVQP 194
            ..|:         ||::.||..||||||..|.|:|||:..|.||....:|::| ..::|..||:|
  Fly   130 TGLQ---------GFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYP-APQVSTAVVEP 184

Human   195 YNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMN 259
            |||:||.....:::||..::||.|:..|....|.|:.|::..:|:|:..|:|:.|.:||:.|.:|
  Fly   185 YNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALN 249

Human   260 NDLIGLIASLIPTPRLHFLMTGYTP-----------LTTDQSVRAAFSVPGQ 300
            .||.....:|:|.||:||.:..|.|           ||..:...|.|....|
  Fly   250 VDLTEFQTNLVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQ 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TUBG2	XP_024306462.1	gamma_tubulin	3..>293	CDD:276957	106/303 (35%)
TUBG2	XP_024306462.1	INTAP	306..>379	CDD:318758
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	109/312 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810