back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC39A1 and Zip89B

DIOPT Version :9

Sequence 1:	NP_001258886.1	Gene:	SLC39A1 / 27173	HGNCID:	12876	Length:	324	Species:	Homo sapiens
Sequence 2:	NP_536747.2	Gene:	Zip89B / 41975	FlyBaseID:	FBgn0038412	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	364	Identity:	100/364 - (27%)
Similarity:	161/364 - (44%)	Gaps:	81/364 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    27 LEVKLGALVLLLVLTLLCSLVPICVLRRPGANHEGSASRQKALSLVSC---FAGGVFLATCLLDL 88
            |..|:.|:|:|...:.:|..:|. :|.|.....|...:.:.|: :|.|   |.|||.|||..|.|
  Fly    53 LVAKVTAMVVLFCASAICGSIPF-LLNRCYRWTENQTNARSAI-VVKCLLYFGGGVLLATTFLHL 115

Human    89 LPDYLAAIDEAL-AALHVTLQFPLQEFILAMGFFLVLVMEQITLAY-----KEQSG--------- 138
            ||:....::|.. ..:...|.|||.|.::..||||:..:|:....|     |:::|
  Fly   116 LPEVQEVVEELQECGIIGELTFPLAELLMCCGFFLMYFIEEAMHTYVHHHQKDEAGAAFERGHSI 180

Human   139 -------------------PSPLEETRALLGTV-----------------------NG-GPQHWH 160
                               |:||..| |.|||:                       || |..|.|
  Fly   181 RNSHLLKPTEGNATTPTAPPAPLAGT-AELGTLSVQNLLQNDLEQQKFATKPQQQANGHGHSHGH 244

Human   161 DGPG-------VPQASGAPATPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHK 218
             |.|       ...|.......|:||...:|.:|:||.:|||:|:||:...:....:..|:..||
  Fly   245 -GHGHSHLPVIADDADAGDMLASSLRGLFIVSALSLHELFEGMAIGLESSASSVWFMFGAVSAHK 308

Human   219 GILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGAAL---AESAGPLHQLAQSVLEGMAA 280
            .:||..:.:.|:.:..|..:.....:.|:.::|||||:|..:   .|::||  .|..::|:|.|.
  Fly   309 LVLAFCVGVELIVARTRMLLAVLYVLTFAVVSPLGIGIGILINHGEETSGP--SLVSAILQGFAC 371

Human   281 GTFLYITFLEILPQELASSEQRILKVILLLAGFALLTGL 319
            ||.:|:.|.||    |:.:...:...:.|..||.::.||
  Fly   372 GTLIYVVFFEI----LSKNRSGLRAYLALFVGFLVMFGL 406

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.