Protein Alignment GLA and CG7997

DIOPT Version :10

• Sequence 1: NP_001393676.1
• Gene: GLA / 2717
• HGNCID: 4296
• Length: 470
• Species: Homo sapiens
• Sequence 2: NP_611119.1
• Gene: CG7997 / 36829
• FlyBaseID: FBgn0034117
• Length: 417
• Species: Drosophila melanogaster
• Alignment Length: 452
• Identity: 191/452 - (42%)
• Similarity: 268/452 - (59%)
• Gaps: 61/452 - (13%)

Human    10 LGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISWSFALVAQA 74
            ||..|.|:.|.|       :..||||||..|.|||:.||||.|..||:..||.||
  Fly     9 LGGILLLQVLQL-------SMGLDNGLALKPPMGWMSWERFRCITDCKLYPDECI---------- 56

Human    75 GVQCHDLGSPQPPPPRFKQFSCLILASSWNYSEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAP 139
                                           |||||...|:|:||||:.||||||:.|||||:..
  Fly    57 -------------------------------SEKLFQRHADLLVSEGYADAGYEYVIIDDCWLEK 90

Human   140 QRDSE-GRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADW 203
            .||:: .:|..|.:|||:|:..|::::|::|||.|:|.|.|..||||:||...:..:||||||||
  Fly    91 NRDNDTQKLVPDRKRFPNGLNALSDHIHNQGLKFGLYQDYGTNTCAGYPGVIKHMKLDAQTFADW 155

Human   204 GVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPF-QKPNYTEIRQYCNHW 267
            .||.:|.||||. ::.::|.||......||.|||.:||||.||.|.... :.|:|..::|:||.|
  Fly   156 DVDYVKLDGCYA-NISDMASGYPEFGRLLNETGRPMVYSCSWPAYQEDAGEMPDYESLKQHCNLW 219

Human   268 RNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMA 332
            ||:.||:||.:|:..|:|:.:.||:||....|||.|||||||::||:|||::|...|||:|||||
  Fly   220 RNWDDIEDSLESLMQIIDYFAKNQDRIQPHGGPGHWNDPDMLLLGNYGLSYDQSKLQMAIWAIMA 284

Human   333 APLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGL------AWA 391
            |||.|||||..:.|:.||:||::.|||::||.||.||.::...:..|||:||::.:      ::|
  Fly   285 APLIMSNDLAAVRPEIKAILQNRAVIAVDQDELGIQGRRVLSRNQIEVWKRPITPVTKSGHHSYA 349

Human   392 VAMINRQEIGGPRSYTIAVASLGKGVACNPACF-ITQLLPVKRKLGFYEWTSRLRSHINPTG 452
            ||.::|::.|.|......|..||   ..||..: :..|.....|||.::..|:..:.:||.|
  Fly   350 VAFVSRRDDGAPYRIPFTVKELG---LTNPKGYNVQDLYDASSKLGVFQSESQFITRVNPNG 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLA	NP_001393676.1	Melibiase_2	39..363	CDD:374582	149/325 (46%)
		Melibiase_2_C	366..452	CDD:407508	26/92 (28%)
CG7997	NP_611119.1	AmyAc_family	32..315	CDD:476817	149/324 (46%)
		Melibiase_2_C	318..408	CDD:407508	26/92 (28%)