Protein Alignment GLA and Gla

DIOPT Version :10

• Sequence 1: NP_001393676.1
• Gene: GLA / 2717
• HGNCID: 4296
• Length: 470
• Species: Homo sapiens
• Sequence 2: NP_001102290.2
• Gene: Gla / 363494
• RGDID: 1589721
• Length: 421
• Species: Rattus norvegicus
• Alignment Length: 459
• Identity: 331/459 - (72%)
• Similarity: 372/459 - (81%)
• Gaps: 41/459 - (8%)

Human     1 MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCIS 65
            |:|.:.:..|.|.||||.||||.|.|.||||||||||||||||||||||||||||||||||:||
  Rat     3 MKLLSGDTPLVCELALRPLALVFWSILGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDACI- 66

Human    66 WSFALVAQAGVQCHDLGSPQPPPPRFKQFSCLILASSWNYSEKLFMEMAELMVSEGWKDAGYEYL 130
                                                    ||:|||:|||||||:||:|||||||
  Rat    67 ----------------------------------------SEQLFMQMAELMVSDGWRDAGYEYL 91

Human   131 CIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDI 195
            |||||||||:|||:|||||||:|||.||:.|||||||||||||||||||.|||||||||||.|||
  Rat    92 CIDDCWMAPERDSKGRLQADPKRFPSGIKHLANYVHSKGLKLGIYADVGKKTCAGFPGSFGSYDI 156

Human   196 DAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEI 260
            |||||||||:||||||||:|||:.:||:|||:|||||||||||||||||||||:.||.|||||:|
  Rat   157 DAQTFADWGIDLLKFDGCHCDSVVSLANGYKYMSLALNRTGRSIVYSCEWPLYLRPFHKPNYTDI 221

Human   261 RQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQM 325
            :.||||||||.|:.|||:||||||.||..:|:.||:||||||||||||||||||||||:||||||
  Rat   222 QYYCNHWRNFDDVYDSWESIKSILAWTVTHQKDIVEVAGPGGWNDPDMLVIGNFGLSWDQQVTQM 286

Human   326 ALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAW 390
            ||||||||||.||||||.||.|||||||::|||||||||||||||..|:.:..||||||||.|||
  Rat   287 ALWAIMAAPLLMSNDLRQISSQAKALLQNEDVIAINQDPLGKQGYCFRKENEIEVWERPLSNLAW 351

Human   391 AVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVL 455
            |||:.|.|||||||.|||.::|||:|:||||.|.|||:||.|..||||||...|::.|||:||||
  Rat   352 AVAVRNLQEIGGPRFYTIQISSLGRGLACNPGCIITQILPEKVHLGFYEWPLTLKTRINPSGTVL 416

Human   456 LQLE 459
            |:||
  Rat   417 LRLE 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLA	NP_001393676.1	Melibiase_2	39..363	CDD:374582	239/323 (74%)
		Melibiase_2_C	366..452	CDD:407508	56/85 (66%)
Gla	NP_001102290.2	AmyAc_family	41..324	CDD:476817	239/323 (74%)
		Melibiase_2_C	327..413	CDD:407508	56/85 (66%)