DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GLA and mel1

DIOPT Version :10

Sequence 1:NP_001393676.1 Gene:GLA / 2717 HGNCID:4296 Length:470 Species:Homo sapiens
Sequence 2:NP_595012.1 Gene:mel1 / 2543243 PomBaseID:SPAC869.07C Length:436 Species:Schizosaccharomyces pombe


Alignment Length:421 Identity:136/421 - (32%)
Similarity:201/421 - (47%) Gaps:101/421 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    10 LGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISWSFALVAQA 74
            |.| ..|.||.|...|:.|:.   |||...|.|||..|.::.|::|                   
pombe     7 LNC-FFLVFLFLFFSDVHGSY---NGLGLKPQMGWNSWNKYACDID------------------- 48

Human    75 GVQCHDLGSPQPPPPRFKQFSCLILASSWNYSEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAP 139
                                            |.:.:..|:.:..||..|.||||:.:||||...
pombe    49 --------------------------------ESIILNNAKAIKEEGLLDLGYEYIVMDDCWSKH 81

Human   140 QRD-SEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADW 203
            :|: :.|||:|:|.:||:||..:|..:|..|.|.|:|:..|..||||||||..:..|||.|||||
pombe    82 ERNATTGRLEANPDKFPNGIGSMAKKLHDMGFKFGMYSSAGKYTCAGFPGSLNHEQIDADTFADW 146

Human   204 GVDLLKFDGCYCDSLENLA----DGYKHMSLALNRTGRSIVYS-CEW-PLYMWPFQKPNYTEIRQ 262
            |||.||:|.|:.:....:.    :.||.||.|||:|||.|.|| |:| ..::|.:.       ..
pombe   147 GVDYLKYDNCFNEGKSGVPLISYERYKRMSDALNKTGRPIFYSLCQWGEDFVWNWG-------NT 204

Human   263 YCNHWRNFADIDDSWK---------------------SIKSILDWTSFNQERIVDVAG-PGGWND 305
            ..|.||...||.|::.                     |:.:|:...||...:    || ..||||
pombe   205 IANSWRISGDIFDTFSRKDVRCPCETIECFALQGDHCSVMNIISKASFLSSK----AGMNSGWND 265

Human   306 PDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQG- 369
            .|.|.:||.|:|:.:..|...:|||:.:||.:.||:..:||..|.::.:|::|:|||| :|... 
pombe   266 LDSLEVGNGGMSFEEYKTHFTMWAILKSPLILGNDVSSMSPMDKLIVSNKELISINQD-IGTNPA 329

Human   370 ---YQLRQGDNF-EVWERPLSGLAWAVAMIN 396
               ::.:.||.: |::...||...|.||::|
pombe   330 ALIWKKKYGDEYIELFSGRLSNNDWVVAVLN 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GLANP_001393676.1 Melibiase_2 39..363 CDD:374582 113/352 (32%)
Melibiase_2_C 366..452 CDD:407508 10/36 (28%)
mel1NP_595012.1 GH27 33..323 CDD:269893 113/351 (32%)
Melibiase_C 339..418 CDD:465512 8/22 (36%)

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