Protein Alignment GLA and gana-1

DIOPT Version :10

• Sequence 1: NP_001393676.1
• Gene: GLA / 2717
• HGNCID: 4296
• Length: 470
• Species: Homo sapiens
• Sequence 2: NP_506031.1
• Gene: gana-1 / 179660
• WormBaseID: WBGene00011095
• Length: 451
• Species: Caenorhabditis elegans
• Alignment Length: 440
• Identity: 174/440 - (39%)
• Similarity: 236/440 - (53%)
• Gaps: 55/440 - (12%)

Human    28 GARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISWSFALVAQAGVQCHDLGSPQPPPPRFK 92
            ||..|||||.|||.|||:.|..|.|.:||.:.|..||
 Worm    12 GAFCLDNGLGRTPPMGWMSWTAFYCEIDCVKHPTGCI---------------------------- 48

Human    93 QFSCLILASSWNYSEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHG 157
                         :|:|:.:||:.:||.|:...||:.:.|||||...:|||.|.|.|:..|||.|
 Worm    49 -------------NEQLYKDMADQLVSGGYDKVGYKSVHIDDCWSEMERDSHGILVANKTRFPSG 100

Human   158 IRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLA 222
            ::.||.|:|.:|||.|||.|.|.|||.|:|||:.:..:||||||.|.||.||.|||..|. ..:.
 Worm   101 MKALAKYMHDRGLKFGIYEDYGTKTCGGYPGSYKHEKVDAQTFAAWDVDYLKLDGCNIDQ-AMMP 164

Human   223 DGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKP---NYTEIRQYCNHWRNFADIDDSWKSIKSIL 284
            .||......||.|||.|:|||.||.|:  ...|   ||..|.:|||.||||.||:.|||||.||:
 Worm   165 IGYPLFEKELNETGRPIMYSCSWPAYL--IDHPELVNYNLIGKYCNTWRNFDDINSSWKSIISII 227

Human   285 DWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAK 349
            .:....|::.:...|||.|:|||||||||.|::.:..::|..:|.|.:|||.||||||.|....|
 Worm   228 SYYDKMQDKHIPTHGPGKWHDPDMLVIGNKGITLDMSISQFTVWCIWSAPLIMSNDLRIIGDSFK 292

Human   350 ALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWER---PLSG--LAWAVAMINRQEIGGPRSYTIA 409
            .:|::|:.|.|||||||..|..::...:..|:.:   |..|  .::|.|.:||.|..|.:...|.
 Worm   293 DVLKNKEAIKINQDPLGIMGRLIKNSTDIGVYVKQITPSKGDKKSFAFAYLNRNEKEGYKRIEIQ 357

Human   410 VASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLE 459
            :||:|   ..:||.:....:.....||.......:...|.|.|:|..:.:
 Worm   358 LASIG---LTDPAGYYVHDIWSHVDLGLLRSGDSIVVSIAPAGSVFFRAD 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLA	NP_001393676.1	Melibiase_2	39..363	CDD:374582	139/326 (43%)
		Melibiase_2_C	366..452	CDD:407508	21/90 (23%)
gana-1	NP_506031.1	AmyAc_family	23..306	CDD:476817	139/326 (43%)
		Melibiase_2_C	309..397	CDD:407508	21/90 (23%)