Protein Alignment GLA and Gla

DIOPT Version :10

• Sequence 1: NP_001393676.1
• Gene: GLA / 2717
• HGNCID: 4296
• Length: 470
• Species: Homo sapiens
• Sequence 2: NP_038491.2
• Gene: Gla / 11605
• MGIID: 1347344
• Length: 421
• Species: Mus musculus
• Alignment Length: 459
• Identity: 327/459 - (71%)
• Similarity: 368/459 - (80%)
• Gaps: 41/459 - (8%)

Human     1 MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCIS 65
            |:|.:.:..|.|.|||..||||.|.|.|.||||||||||||||||||||||||||||||||:||
Mouse     3 MKLLSRDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCNLDCQEEPDACI- 66

Human    66 WSFALVAQAGVQCHDLGSPQPPPPRFKQFSCLILASSWNYSEKLFMEMAELMVSEGWKDAGYEYL 130
                                                    ||:|||:|||||||:||:||||:||
Mouse    67 ----------------------------------------SEQLFMQMAELMVSDGWRDAGYDYL 91

Human   131 CIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDI 195
            |||||||||:|||:|||||||||||.||:.|||||||||||||||||||||||||||||||.|||
Mouse    92 CIDDCWMAPERDSKGRLQADPQRFPSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGSFGSYDI 156

Human   196 DAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEI 260
            ||||||||||||||||||:|||:.:|.:|||:|:|||||||||||||||||||:.||.|||||:|
Mouse   157 DAQTFADWGVDLLKFDGCHCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPFHKPNYTDI 221

Human   261 RQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQM 325
            :.||||||||.|:.|||:|||:||.||...|:.||:|||||.||||||||||||||||:||||||
Mouse   222 QYYCNHWRNFDDVYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQM 286

Human   326 ALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAW 390
            ||||||||||.||||||.||.|||||||:||||||||||||||||..|:.::.||||||||.|||
Mouse   287 ALWAIMAAPLLMSNDLRQISSQAKALLQNKDVIAINQDPLGKQGYCFRKENHIEVWERPLSNLAW 351

Human   391 AVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVL 455
            |||:.|.||||||..|||.::|||:|:||||.|.||||||.|..|||||||..|::.:||:||||
Mouse   352 AVAVRNLQEIGGPCPYTIQISSLGRGLACNPGCIITQLLPEKVHLGFYEWTLTLKTRVNPSGTVL 416

Human   456 LQLE 459
            .:||
Mouse   417 FRLE 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLA	NP_001393676.1	Melibiase_2	39..363	CDD:374582	238/323 (74%)
		Melibiase_2_C	366..452	CDD:407508	56/85 (66%)
Gla	NP_038491.2	AmyAc_family	41..324	CDD:476817	238/323 (74%)
		Melibiase_2_C	327..413	CDD:407508	56/85 (66%)