DRSC/TRiP Functional Genomics Resources

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Protein Alignment GLA and gla

DIOPT Version :10

Sequence 1:NP_001393676.1 Gene:GLA / 2717 HGNCID:4296 Length:470 Species:Homo sapiens
Sequence 2:NP_001120606.1 Gene:gla / 100145767 XenbaseID:XB-GENE-1008596 Length:408 Species:Xenopus tropicalis


Alignment Length:441 Identity:264/441 - (59%)
Similarity:320/441 - (72%) Gaps:42/441 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    19 LALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISWSFALVAQAGVQCHDLGS 83
            |..|.|. .||::|.||||.||.|||||||||:|..:|:..|.:||                   
 Frog    10 LGTVLWP-QGAQSLQNGLALTPPMGWLHWERFLCETNCERNPKNCI------------------- 54

Human    84 PQPPPPRFKQFSCLILASSWNYSEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQ 148
                                  ||:|||:||:.||||||.||||:||||||||:||:||.:.|||
 Frog    55 ----------------------SEQLFMDMADKMVSEGWLDAGYQYLCIDDCWLAPERDEKNRLQ 97

Human   149 ADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGC 213
            |||.|||.||::||:||||:||.||||.|||:|||.|||||.|||||||||||:|||||||||||
 Frog    98 ADPVRFPGGIKKLADYVHSRGLLLGIYEDVGSKTCEGFPGSQGYYDIDAQTFAEWGVDLLKFDGC 162

Human   214 YCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWK 278
            |..:|:.|.|||:.||:|||||||.||.|||||||....:|.||:|:.:|||.||||.||.|||.
 Frog   163 YYGTLDKLEDGYRQMSMALNRTGRKIVLSCEWPLYERGIKKINYSEVAEYCNSWRNFGDITDSWG 227

Human   279 SIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRH 343
            |:|:::|.:|..||.||.|||||.||||||||||||||||||||||||||:||||||.||||||.
 Frog   228 SVKAVMDLSSAVQEEIVPVAGPGSWNDPDMLVIGNFGLSWNQQVTQMALWSIMAAPLMMSNDLRD 292

Human   344 ISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTI 408
            |..::|||||||:||:|||||||.|||::.:.|.||||||||...:.|||:.||.||||||::.:
 Frog   293 IPAESKALLQDKNVISINQDPLGAQGYRVFKADYFEVWERPLIKGSLAVAVTNRNEIGGPRNFLL 357

Human   409 AVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLE 459
            :::.|.:...|..:||||||||..:|.|....||.|...|||:||:||:::
 Frog   358 SLSLLWEDRVCQNSCFITQLLPSFQKYGHLNDTSLLSLWINPSGTILLRID 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GLANP_001393676.1 Melibiase_2 39..363 CDD:374582 204/323 (63%)
Melibiase_2_C 366..452 CDD:407508 42/85 (49%)
glaNP_001120606.1 AmyAc_family 29..312 CDD:476817 204/323 (63%)
Melibiase_2_C 315..401 CDD:407508 42/85 (49%)

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