DRSC/TRiP Functional Genomics Resources

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Protein Alignment SALL3 and salm

DIOPT Version :9

Sequence 1:NP_741996.2 Gene:SALL3 / 27164 HGNCID:10527 Length:1300 Species:Homo sapiens
Sequence 2:NP_723670.2 Gene:salm / 34569 FlyBaseID:FBgn0261648 Length:1365 Species:Drosophila melanogaster


Alignment Length:1408 Identity:401/1408 - (28%)
Similarity:549/1408 - (38%) Gaps:476/1408 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     4 RKQAKPQHLKSDEE----LLPPDGAPEHAAPGEGAEDADSGPESRSGGEETSVCEKCCAEFFKWA 64
            |.::..:.:.||:|    ..|...|...|:|....|..:..||.:|..|: |:.|:...:.....
  Fly    44 RARSADKDIGSDQEENGGCSPLTTATTTASPSRSPEPEEEQPEEQSTSEQ-SIPEQSTPDHQLEN 107

Human    65 DFLEHQRSCTKLPPVLIVHED-----APAPPPEDFPEPSPASS-PSERAESEAAEEAGAEGAEGE 123
            |.....:|  ::.||    ||     |...|..:..||:.:.| ||......:||||..|     
  Fly   108 DIKSEAKS--EIEPV----EDNNNRVAMTKPSSEEREPNASGSMPSSPVAEASAEEAATE----- 161

Human   124 ARPVEKEAEPMDAEPAGDTRAPRPPPAAPAPPTP-----AYGAPSTNVTLEALLSTKVAVAQFSQ 183
             |..|||.| .|.|.  |...|...|::..|.|.     ..|||   |||||:.:.::|:|||:.
  Fly   162 -RTPEKEKE-KDVEV--DVEKPDEAPSSAVPSTEVTLPGGAGAP---VTLEAIQNMQMAIAQFAA 219

Human   184 GARAAGGSGAGGGVAAAAVPLILEQLMALQQQQIHQLQLIEQIRSQVALMQ-------------- 234
            ...|.|.:||....|...:..:.:.|..|||||:.|:|||:|::||:||.|              
  Fly   220 KTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQE 284

Human   235 --------------RPPPRPSLSPAAAPSAPGPAPSQLPGLAALPLSAGAPAAAIAGSGPAAPAA 285
                          |.........|.|..|...|...|       ::||.|....:||       
  Fly   285 QDQEQETDTYEEEERIADMELRQKAEARMAEAKARQHL-------INAGVPLRESSGS------- 335

Human   286 FEGAQPLSRPESGASTPGGPAEPSAPAAPSAAPAPAAPAPAPAPQSAASSQPQSASTPPALAPGS 350
              .|:.|.|..          |....:.|:..|:......|...|.|.:...:..:||  |..||
  Fly   336 --PAESLKRRR----------EHDHESQPNRRPSLDNTHKADTAQDALAKLKEMENTP--LPFGS 386

Human   351 LLGAA-----PGLPSP----LLPQ------TSASGVIFPNPLVSIAATANALDPLSALMKHRKGK 400
            .|.::     ..||.|    ||.:      .|||..|..|.:.         |..:...|..:||
  Fly   387 DLASSIITNHDDLPEPNSLDLLQKRAQEVLDSASQGILANSMA---------DDFAFGEKSGEGK 442

Human   401 PPNVSVFEPKASAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKV 465
            ..|           :|||||:||:|.||||||||||||:||||||||||||:||:||:|||||||
  Fly   443 GRN-----------EPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKV 496

Human   466 HFQRHKEKYPHIQMNPYPVPEYLD--NVPTCSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTSVGL 528
            |||||.:|:||:.||..|:||::|  :.|....:....|.|...|      :.|.|.:.|.|   
  Fly   497 HFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSSPNHSP------APPPLGSAPAS--- 552

Human   529 QLPPTVPGAHGYADSP--------SATPASRSPQ-------RPSP-------------------- 558
             .||..||.......|        :|.|....||       :|||                    
  Fly   553 -FPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDEDEPQVKNEPVEEKDQR 616

Human   559 -----ASSECASLSPGLNHVESGV--------------------------SATAESP----QSLL 588
                 ..:||:...|....:|..:                          |:...||    .|.:
  Fly   617 EEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHM 681

Human   589 GGPPLTKAEPVSLPCTNARAGDAPVGAQASAAPTSVDGAPTSLG---SPG-LPAVSEQFKAQFPF 649
            |.||:.:                |:...|...|.|..|:.:.|.   :|| ||...:.|..:||.
  Fly   682 GYPPVVQ----------------PIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPL 730

Human   650 --------------------GGLL----------------------------------------- 653
                                ||.|                                         
  Fly   731 NFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKHEMAALLPRPHSNDNS 795

Human   654 -----DSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICG 713
                 :...|.||.||::|::|  ||::||||||:|.|||||:|||:||||||||||||||:|||
  Fly   796 WENFIEVSNTCETMKLKELMKN--KKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICG 858

Human   714 RAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTP-------- 770
            ||||||||||||..||:.:||:|..|.||:|.||::||:|||||||:|.|.....||        
  Fly   859 RAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEI 923

Human   771 -------------------------LPEG-----------FQDAMDSELAYD--DKNAETLSSYD 797
                                     ||.|           ...|:.||.:..  |.|.:....||
  Fly   924 RDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCGEDYD 988

Human   798 DD-----MDENSMEDDAELK-----------------DAA----TDPAKPLL-------SYAGSC 829
            ||     :..:::|.:.:..                 ||.    |:|.:|..       |...:.
  Fly   989 DDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTS 1053

Human   830 PPSPPSV---------ISSIAALENQMKMID---------SVMSCQQLTGLKSV------ENGSG 870
            .|:.|||         .||.|..|.....:|         |..|...|...|.|      .:.||
  Fly  1054 APTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSG 1118

Human   871 ESDRLSNDSSS----AVG----------------------------------------------- 884
            .|...:|..:|    .||                                               
  Fly  1119 SSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQ 1183

Human   885 --------DLESRSAGSPALSESSSSQALSPAPSNGESFRSKSPGLGAPEEPQEIPLKTERPD-- 939
                    :.:.::|.:.|.:.::::......|...:..:...||.|.|..    ||...||.  
  Fly  1184 EQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPN----PLMGARPPFG 1244

Human   940 --------SPAAAPGSGGAPGR--AGIKEEAPFSLLFLSRERGKCPSTVCGVCGKPFACKSALEI 994
                    .||.......|..:  ..:...|||:.|.||..||   ||.||:|.|.|.|.|||||
  Fly  1245 MFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRG---STTCGICYKTFPCHSALEI 1306

Human   995 HYRSHTKERPFVCALCRRGCSTMGNLKQHLLTHRLKELPSQLF 1037
            |||||||||||.|::|.||.:|.||||||:|||:::::..:.|
  Fly  1307 HYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETF 1349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SALL3NP_741996.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 13/50 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 84..162 27/88 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..258 6/51 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..352 16/74 (22%)
COG5048 412..>734 CDD:227381 159/463 (34%)
C2H2 Zn finger 422..442 CDD:275368 16/19 (84%)
C2H2 Zn finger 450..470 CDD:275368 16/19 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..633 31/182 (17%)
C2H2 Zn finger 681..701 CDD:275368 15/19 (79%)
zf-H2C2_2 693..718 CDD:316026 22/24 (92%)
C2H2 Zn finger 709..729 CDD:275368 16/19 (84%)
zf-C2H2 739..761 CDD:306579 15/21 (71%)
C2H2 Zn finger 741..761 CDD:275368 14/19 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 864..955 22/167 (13%)
C2H2 Zn finger 979..999 CDD:275368 14/19 (74%)
C2H2 Zn finger 1007..1027 CDD:275368 12/19 (63%)
zf-C2H2 1113..1135 CDD:306579
C2H2 Zn finger 1115..1135 CDD:275368
zf-H2C2_2 1127..1152 CDD:316026
C2H2 Zn finger 1143..1163 CDD:275368
zf-C2H2 1143..1163 CDD:306579
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1259..1279
salmNP_723670.2 zf-C2H2 451..473 CDD:278523 17/21 (81%)
C2H2 Zn finger 453..473 CDD:275368 16/19 (84%)
zf-H2C2_2 465..490 CDD:290200 21/24 (88%)
C2H2 Zn finger 481..501 CDD:275368 16/19 (84%)
C2H2 Zn finger 826..846 CDD:275368 15/19 (79%)
zf-H2C2_2 838..863 CDD:290200 22/24 (92%)
zf-C2H2_2 854..922 CDD:289522 40/67 (60%)
C2H2 Zn finger 854..874 CDD:275368 16/19 (84%)
C2H2 Zn finger 886..906 CDD:275368 14/19 (74%)
C2H2 Zn finger 1291..1311 CDD:275368 14/19 (74%)
zf-H2C2_2 1303..1328 CDD:290200 19/24 (79%)
C2H2 Zn finger 1319..1339 CDD:275368 12/19 (63%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11476
eggNOG 1 0.900 - - E1_KOG1074
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 448 1.000 Inparanoid score I1625
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D130294at33208
OrthoFinder 1 1.000 - - FOG0001008
OrthoInspector 1 1.000 - - otm41403
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23233
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1943
SonicParanoid 1 1.000 - - X498
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.960

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