Protein Alignment CHIA and Cht4

DIOPT Version :10

• Sequence 1: NP_970615.2
• Gene: CHIA / 27159
• HGNCID: 17432
• Length: 476
• Species: Homo sapiens
• Sequence 2: NP_524962.2
• Gene: Cht4 / 49815
• FlyBaseID: FBgn0022700
• Length: 462
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 184/494 - (37%)
• Similarity: 264/494 - (53%)
• Gaps: 66/494 - (13%)

Human     7 LTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQN-NEITTIE 70
            |..|.|.|.....|...|.||:..||.||||.|:|.|.:|||.||||:.|.|.|..: .|..:::
  Fly     9 LAALCLCLGQVASSEKLLNCYWGTWANYRPGDGKFTPSDIDPSLCTHISYTFFGISDAGEFKSLD 73

Human    71 -WNDVT-----LYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQ 129
             |.|:.     :.|.. .||.:|..||.|..:||||.|:..::||.:.|..|.||:::.:.|::|
  Fly    74 TWLDMDDGLGFISQTI-ALKQRNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTSLAFIQQ 137

Human   130 YEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSG 194
            |.|||||.||||||.||....|:..|..|::|::|.::|...::.       .||.|...:....
  Fly   138 YSFDGLDLDWEYPGQRGGSEADRENFVTLLREIKETYDQYGLELG-------IAVGASEKSASIS 195

Human   195 YEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEK 259
            |:||.:||:|.:|:|||||.|.:.:||.|.|:||.:            |...::||..:||||||
  Fly   196 YDIPAISQHLTFINVMTYDFHMALDGYLGLNAPLPE------------VAESIDYWLSHGAPAEK 248

Human   260 LIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEV 324
            ||:|...|||::.:|:.|....||...|.|.||.|.:|:|...|:|||  |.|..|. :|.....
  Fly   249 LILGIGFYGHSYQMSDSSQNWPGAACIGPGTAGVYTRENGFLGYHEIC--LNNWQTV-FDQENGA 310

Human   325 PYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGL 389
            |||:||:.|:||||.:|..:|.|.::....||||:|:|:.|||.| .|.: .:||:.|:.:|||.
  Fly   311 PYAFQGDQWIGYDNPESIQLKMQLVESRNLGGAMMWSIETDDFRG-LCGE-SYPLLKTMNRALGR 373

Human   390 QSASCTAPAQPIEPITAAPSGSGNGSGSSS------------------SGGSSGGSGFCAVRANG 436
            :             ::....|.|.|.|..|                  .||.|||:. ||  .:|
  Fly   374 E-------------VSGGSGGGGGGGGEGSVTPAPTAAPTSSPTPAPTPGGGSGGNE-CA--QDG 422

Human   437 LYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNW 475
            .:.:.::.|.|:.||.||.|...|.|||.|:|....|:|
  Fly   423 FFVLESDCNKFYQCVGGVRYDFQCGAGLCFNTITLNCDW 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHIA	NP_970615.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	148/369 (40%)
		ChtBD2	429..476	CDD:214696	18/47 (38%)
Cht4	NP_524962.2	GH18_chitolectin_chitotriosidase	26..371	CDD:119351	148/369 (40%)
		CBM_14	420..462	CDD:426342	16/42 (38%)