Protein Alignment CHIA and Cht2

DIOPT Version :10

• Sequence 1: NP_970615.2
• Gene: CHIA / 27159
• HGNCID: 17432
• Length: 476
• Species: Homo sapiens
• Sequence 2: NP_477298.2
• Gene: Cht2 / 38223
• FlyBaseID: FBgn0022702
• Length: 484
• Species: Drosophila melanogaster
• Alignment Length: 449
• Identity: 156/449 - (34%)
• Similarity: 226/449 - (50%)
• Gaps: 56/449 - (12%)

Human    24 LTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNE--ITTIE-WNDVTL------YQA 79
            :.||.:.||.|||..|.:..:|.||.||||::|||||....:  |.::: |.|:..      |:.
  Fly    43 VVCYVSTWAVYRPEQGAYAIENFDPNLCTHVVYAFAGLDITQAAIKSLDPWQDLKEEYGKGGYEK 107

Human    80 FNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGS 144
            ..|||..:..||..|||||||.|:|.::.:|:....|..|:..|..|:|:|.|||||.|||||..
  Fly   108 MTGLKRSHPHLKVSLAIGGWNEGSANYSTLVANNLLRGRFVKQVSSFIRKYNFDGLDLDWEYPTQ 172

Human   145 RGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHV 209
            |...|.|:..|.:|.:|:||.|::..       |::|:|:.|....|...|::.|:|:||||:|:
  Fly   173 RKGKPADRENFVLLTKELREEFDEHG-------LLLTSAIGASKKVIDEAYDVRQISRYLDYLHI 230

Human   210 MTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILS 274
            |.||.||||:...|.|:|| ..|.|...:...::||::..    |||.|||::|.|.||..|  .
  Fly   231 MCYDYHGSWDRRVGYNAPL-TAPADDPLSVKFSIDYLLKL----GAPPEKLVMGLPFYGRTF--K 288

Human   275 NPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKN---GATQGWDAPQ--EVPYAYQGNVW- 333
            ..::..:...:.|.|..|||.:|.|...|.|||..|.|   |.|:.|| ||  :|....:.||:
  Fly   289 TLASGFLNDVSEGVGFKGPYTREDGFLGYNEICQTLSNQTSGWTREWD-PQTSQVLAKSERNVFT 352

Human   334 -----VGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFC-------------------NQ 374
                 |.||:.:|...|..:....:..|.|||::|.|||.|. |                   :.
  Fly   353 QEINVVTYDSSRSIANKVLFAMSKRLAGVMVWSVDTDDFLGN-CKLDEDTYEDFQKVTAAPKRSS 416

Human   375 GKFPLISTLKKALGLQSASCTAP-AQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAV 432
            ..:||:.|:.:|..|.......| .||.:.....|.||.....::.:...|.|.|..||
  Fly   417 QNYPLLRTINEATMLAVDELAVPEPQPDDSENEIPHGSIADRKNAGASMVSLGLGVTAV 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHIA	NP_970615.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	143/401 (36%)
		ChtBD2	429..476	CDD:214696	2/4 (50%)
Cht2	NP_477298.2	GH18_chitolectin_chitotriosidase	43..428	CDD:119351	143/400 (36%)