DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHIA and Cht2

DIOPT Version :9

Sequence 1:	NP_970615.2	Gene:	CHIA / 27159	HGNCID:	17432	Length:	476	Species:	Homo sapiens
Sequence 2:	NP_001246550.1	Gene:	Cht2 / 38223	FlyBaseID:	FBgn0022702	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	156/449 - (34%)
Similarity:	226/449 - (50%)	Gaps:	56/449 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    24 LTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNE--ITTIE-WNDVTL------YQA 79
            :.||.:.||.|||..|.:..:|.||.||||::|||||....:  |.::: |.|:..      |:.
  Fly    43 VVCYVSTWAVYRPEQGAYAIENFDPNLCTHVVYAFAGLDITQAAIKSLDPWQDLKEEYGKGGYEK 107

Human    80 FNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGS 144
            ..|||..:..||..|||||||.|:|.::.:|:....|..|:..|..|:|:|.|||||.|||||..
  Fly   108 MTGLKRSHPHLKVSLAIGGWNEGSANYSTLVANNLLRGRFVKQVSSFIRKYNFDGLDLDWEYPTQ 172

Human   145 RGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHV 209
            |...|.|:..|.:|.:|:||.|::..       |::|:|:.|....|...|::.|:|:||||:|:
  Fly   173 RKGKPADRENFVLLTKELREEFDEHG-------LLLTSAIGASKKVIDEAYDVRQISRYLDYLHI 230

Human   210 MTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILS 274
            |.||.||||:...|.|:|| ..|.|...:...::||::..    |||.|||::|.|.||..|  .
  Fly   231 MCYDYHGSWDRRVGYNAPL-TAPADDPLSVKFSIDYLLKL----GAPPEKLVMGLPFYGRTF--K 288

Human   275 NPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKN---GATQGWDAPQ--EVPYAYQGNVW- 333
            ..::..:...:.|.|..|||.:|.|...|.|||..|.|   |.|:.|| ||  :|....:.||:
  Fly   289 TLASGFLNDVSEGVGFKGPYTREDGFLGYNEICQTLSNQTSGWTREWD-PQTSQVLAKSERNVFT 352

Human   334 -----VGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFC-------------------NQ 374
                 |.||:.:|...|..:....:..|.|||::|.|||.|. |                   :.
  Fly   353 QEINVVTYDSSRSIANKVLFAMSKRLAGVMVWSVDTDDFLGN-CKLDEDTYEDFQKVTAAPKRSS 416

Human   375 GKFPLISTLKKALGLQSASCTAP-AQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAV 432
            ..:||:.|:.:|..|.......| .||.:.....|.||.....::.:...|.|.|..||
  Fly   417 QNYPLLRTINEATMLAVDELAVPEPQPDDSENEIPHGSIADRKNAGASMVSLGLGVTAV 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHIA	NP_970615.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	143/401 (36%)
		Glyco_18	26..365	CDD:214753	135/358 (38%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		1/2 (50%)
		ChtBD2	429..476	CDD:214696	2/4 (50%)
Cht2	NP_001246550.1	Glyco_18	42..389	CDD:214753	135/360 (38%)
Cht2	NP_001246550.1	GH18_chitolectin_chitotriosidase	43..428	CDD:119351	143/400 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D826687at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930