DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHIA and Cht9

DIOPT Version :9

Sequence 1:	NP_970615.2	Gene:	CHIA / 27159	HGNCID:	17432	Length:	476	Species:	Homo sapiens
Sequence 2:	NP_611543.3	Gene:	Cht9 / 37392	FlyBaseID:	FBgn0034582	Length:	368	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	152/392 - (38%)
Similarity:	213/392 - (54%)	Gaps:	31/392 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG-RQNN 64
            |.||:.|.. ||.|:..:|:...:.||:..||.||.|.|:|...|||..|||||.|:|.| ..|.
  Fly     1 MGKLLALLA-VLCLSQVIGAERIVNCYWGTWANYRSGNGKFDVSNIDAGLCTHLSYSFFGINDNG 64

Human    65 EITTIE-WNDVTL---YQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIK 125
            ||.::: |.|..|   .||.: |||:||.||.|..:||||.|:..:::|......||.||.|.:.
  Fly    65 EIQSLDTWLDYDLGFINQAIS-LKNQNSNLKVLAVVGGWNEGSTKYSSMSGDWYKRQNFINSALN 128

Human   126 FLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISN 190
            .||.:.|||||.|||||..||....|:..|..|::|::|||.....::.       .||.||.|.
  Fly   129 LLRNHGFDGLDLDWEYPNQRGGNWNDRANFVTLLREIKEAFAPYGYELG-------IAVGAGESL 186

Human   191 IQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGA 255
            ..:.|||..::|.:|:|:|||||...:.:|.||.|:|.:.            |:..:|:|...||
  Fly   187 ASASYEIANIAQQVDFINVMTYDFAMASDGQTGFNAPQWA------------VENAINFWLSQGA 239

Human   256 PAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDA 320
            ||.||::|..|||.:|.||:.|....|||..|.|.||.|...:|...|.|||   :|.....:|.
  Fly   240 PANKLVLGVGTYGRSFQLSDSSQNWPGAPCRGEGSAGSYTGSTGYLGYNEIC---QNNWHTVFDY 301

Human   321 PQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKK 385
            ....||||.|:.||.:||:.|...|..:.......|||:|:::.||:.|. |.: .:||:.|:.:
  Fly   302 DNAAPYAYSGDQWVSFDNVLSVQYKMDFALSKGLAGAMIWSLETDDYRGQ-CGE-TYPLLKTINR 364

Human   386 AL 387
            .|
  Fly   365 KL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHIA	NP_970615.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	143/367 (39%)
		Glyco_18	26..365	CDD:214753	136/343 (40%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		2/2 (100%)
		ChtBD2	429..476	CDD:214696
Cht9	NP_611543.3	GH18_chitolectin_chitotriosidase	23..366	CDD:119351	143/367 (39%)
Cht9	NP_611543.3	Glyco_18	23..346	CDD:214753	136/345 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930