back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHIA and Cht12

DIOPT Version :9

Sequence 1:	NP_970615.2	Gene:	CHIA / 27159	HGNCID:	17432	Length:	476	Species:	Homo sapiens
Sequence 2:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	133/494 - (26%)
Similarity:	220/494 - (44%)	Gaps:	81/494 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG----- 60
            |..:.|:.|.:       ...|.:.|.:...:.|..|..:|...::|..|||||:.. :|
  Fly     9 MIMIFLICGCI-------AKEYNVFCQYDLGSYYYKGRSQFFEWHLDSRLCTHLVLG-SGIGVDG 65

Human    61 -----RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKT---------LLAIGGWNFGTAPFTAMVS 111
                 |..::|..:|             |:|.|.:||         :..||||...::.|:.||:
  Fly    66 DSGELRITDKILLLE-------------KDKLSSVKTMKWDSIKKVMFTIGGWEEDSSSFSRMVA 117

Human   112 TPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKP 176
            :|:.|..|.:|:::|:.::.|||:..||.||...|..|.|:..|.:|::|:...|       .|.
  Fly   118 SPKKRDNFYSSMLEFMFRWGFDGVQIDWRYPTLLGGHPDDRQNFVILLEELGLIF-------RKN 175

Human   177 RLMVTAAVAAGISN-IQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY 240
            :|::..||.....| |...|.||::..:.|:||:|.:|....:......|:||..|....
  Fly   176 QLILMVAVLGRRDNRILESYNIPEIVNHSDFIHLMMHDEQDPYHLRLAYNAPLVGYEGSV----- 235

Human   241 LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYE 305
              .|.:| :||.||...||||:|.|.:..:|.:....:| :|:...|.|.....:...|...|.|
  Fly   236 --TDSIM-HWKRNGGAPEKLILGIPLFVRSFTMDRNQST-VGSACKGPGRQTKQSHRPGFMTYNE 296

Human   306 ICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGT 370
            .|. .::..::.:|...:||||.:|:.||.|:|.:|...|...|:.:|.||||.|.||:|||.|.
  Fly   297 WCV-QQSKWSRMFDQLAKVPYATRGDQWVSYENPRSIWAKMHLLQEHKLGGAMAWTIDVDDFRGR 360

Human   371 FCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRAN 435
             |.: :..|:..:..|||.::...|.     :|.|.|       ||.....|.|.....|.:
  Fly   361 -CGE-QHGLLRVIFSALGDKNGLTTE-----KPTTEA-------SGLCPHDGFSRDGWDCRL--- 408

Human   436 GLYPVANNRNAFWHCVNGVTYQQN---CQAGLVFDTSCD 471
             .:...:....::.|:.|..:.:|   |:...  :..||
  Fly   409 -YHECRDGERIYYECLEGQYFDENQIVCRPAA--EVKCD 444

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.