DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF777 and CG6654

DIOPT Version :9

Sequence 1:	XP_005250037.1	Gene:	ZNF777 / 27153	HGNCID:	22213	Length:	875	Species:	Homo sapiens
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	162/588 - (27%)
Similarity:	236/588 - (40%)	Gaps:	138/588 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   345 NLSEWQKELYKNVMRGNYESLVSMDYAISKPDLMSQMERGE--RPTMQEQEDSEEGETPTDPSAA 407
            |.|...::|..|.:....:|.||:...::..|...|....|  |.|...|.|:   .|.||....
  Fly    71 NSSRTLRQLLPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDA---VTTTDAEQN 132

Human   408 HDGIVIKIEVQTNDEGSESLETPEPLMGQVEEHGFQDSELGDPCGEQPDLDMQEPENTLEEST-- 470
            ...|...|.|..:.||.          |:|.::...|    :|..:...|.:|...|..:|..
  Fly   133 TSLIKSTISVDLDYEGE----------GEVFDYELPD----EPVEKTTSLILQVQGNLKDEKEVV 183

Human   471 --------EGSSEFSELKQMLVQQRNCT----EGI----------------------VIKTEEQD 501
                    ||...  ||:|   |.|.|.    ||:                      ::..:|.|
  Fly   184 FTQTNVIYEGDDH--ELEQ---QIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQEND 243

Human   502 ---------EEEEEEEEDELPQHLQSLGQLSGRYEASMYQTPLPGEMSPEGEESPPPLQLGNPAV 557
                     ||..|.|::::||..:...:..|..:..:..|| |.:..|    ||...:||.
  Fly   244 KHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATP-PSDAEP----SPKQHRLGT--- 300

Human   558 KRLAPSVHGERHLSENR-----GASSQQQRNRRGERPFTCMECGKSFRLKINLIIHQRNHIKEG- 616
                     :|.||..|     |.|:........|..:.|..|...|.::.:|:||:|   ::|
  Fly   301 ---------QRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR---QKGC 353

Human   617 ---PYECAECEISFRHKQQLTLHQRIHRVRGGCVSPERGPTFNPKHALKPRPKSPSSGSGGGGPK 678
               .|:|.|||..|.....|..||..|..
  Fly   354 INRNYKCNECEKVFVSPDHLAEHQASHGA------------------------------------ 382

Human   679 PYKCPECDSSFSHKSSLTKHQIT-HTGERPYTCPECKKSFRLHISLVIHQRVHAGKHEVSFICSL 742
             :.||||......|.:|:||.:. |.......|..|:|.|.:..:|..|.|:|.|  |..|:|::
  Fly   383 -HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTG--EKPFVCNI 444

Human   743 CGKSFSRPSHLLRHQRTHTGERPFKCPECEKSFSEKSKLTNHCRVHSRERPHACPECGKSFIRKH 807
            |||||::.::|.:|:..|:..:.|||..|..||..|::||:|.|.|:.::|..|..|...|....
  Fly   445 CGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSC 509

Human   808 HLLEHRRIHTGERPYHCAECGKRFTQKHHLLEHQRAHTGERPYPCTHCAKCFRYKQSLKYHLRTH 872
            .|.:|:|.|||||||.|..|..|||..:.|..|:|.|||||||.|..|:|.|..:...:.|.|||
  Fly   510 SLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTH 574

Human   873 TGE 875
            .||
  Fly   575 QGE 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF777	XP_005250037.1	KRAB	329..387	CDD:214630	10/43 (23%)
		KRAB_A-box	329..368	CDD:143639	6/22 (27%)
		zf-C2H2	590..612	CDD:278523	7/21 (33%)
		C2H2 Zn finger	592..612	CDD:275368	7/19 (37%)
		zf-H2C2_2	604..629	CDD:290200	11/28 (39%)
		C2H2 Zn finger	620..640	CDD:275368	8/19 (42%)
		CpXC	681..>730	CDD:291051	16/49 (33%)
		C2H2 Zn finger	682..702	CDD:275368	8/20 (40%)
		COG5048	<684..870	CDD:227381	73/186 (39%)
		zf-H2C2_2	694..717	CDD:290200	7/23 (30%)
		C2H2 Zn finger	713..730	CDD:275370	6/16 (38%)
		zf-C2H2	738..760	CDD:278523	9/21 (43%)
		C2H2 Zn finger	740..760	CDD:275368	8/19 (42%)
		zf-H2C2_2	752..776	CDD:290200	8/23 (35%)
		C2H2 Zn finger	768..788	CDD:275368	9/19 (47%)
		zf-H2C2_2	781..805	CDD:290200	9/23 (39%)
		C2H2 Zn finger	796..816	CDD:275368	6/19 (32%)
		zf-H2C2_2	808..833	CDD:290200	14/24 (58%)
		C2H2 Zn finger	824..844	CDD:275368	8/19 (42%)
		zf-H2C2_2	836..861	CDD:290200	14/24 (58%)
		C2H2 Zn finger	852..872	CDD:275368	6/19 (32%)
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	2/7 (29%)
		C2H2 Zn finger	331..354	CDD:275368	8/25 (32%)
		COG5048	<357..570	CDD:227381	84/251 (33%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	8/20 (40%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	13/25 (52%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	7/16 (44%)
		zf-H2C2_2	482..507	CDD:290200	9/24 (38%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	13/23 (57%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910