DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INVS and Invs

DIOPT Version :9

Sequence 1:	NP_055240.2	Gene:	INVS / 27130	HGNCID:	17870	Length:	1065	Species:	Homo sapiens
Sequence 2:	XP_038965783.1	Gene:	Invs / 313228	RGDID:	1563359	Length:	1077	Species:	Rattus norvegicus

Alignment Length:	1087	Identity:	867/1087 - (79%)
Similarity:	918/1087 - (84%)	Gaps:	34/1087 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCAD 65
            ||.|||:|..|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MNISENVLSTGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCAD 65

Human    66 ALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCL 130
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||:|||||||||
  Rat    66 ALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCL 130

Human   131 ALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
            ||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||.
  Rat   131 ALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDA 195

Human   196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLH 260
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
  Rat   196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLH 260

Human   261 WAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFA----------------------E 303
            ||||||||||||||||||||||:|||||||||||||||||||                      |
  Rat   261 WAALLGHAQIVHLLLERNKSGTVPSDSQGATPLHYAAQSNFAVLHYHGPDVPHHCAVSNKVFLQE 325

Human   304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSG 368
            ||||||.||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 TVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSG 390

Human   369 HVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALG 433
            |||||||||:|:||||||||||||||||||||||:||||||||||||||||||||||||||||||
  Rat   391 HVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALG 455

Human   434 GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCN 498
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCN 520

Human   499 NGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQ 563
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 NGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQ 585

Human   564 AVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLPS 628
            |||||||||||||||||||||||||||||||||||||||||||| |||:...|..|||.|||.||
  Rat   586 AVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAE-QKGQPDTDPPRPQVLPCPPS 649

Human   629 TQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRGSPGGSLGGALQKEQHVSSDLQGTNSRRPNETAR 693
            .|:.|||||.||||||||.:..|.|:|  .:|.|.|...|. ...:..|||||||.||:|:|:.|
  Rat   650 PQNEPSRQSAAPSKQPPASHTVQSPDP--EQGRPAGQCPGR-ASHRDCSSDLQGTASRKPSESPR 711

Human   694 EHSKGQSACVHFRPNEGSDGSRHPGVPSVEKSRGETAGD-ERCAKGKGFVKQPSCIRVAGPDEKG 757
            ||.:|.||.||.|..|..|..||.|..|.||.||||:|: :||.:|....:||.....|||.|||
  Rat   712 EHCRGASAGVHPRSCEDGDSYRHQGTSSAEKCRGETSGEHQRCEQGPSRARQPVSTGSAGPAEKG 776

Human   758 EDSRRAAASLPPHDSHWKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGSARGEAVHAG 822
            |||..|..|....|...|||:|.|..|:::.|.|||||.:|| .|||||||||||||:.|...|.
  Rat   777 EDSSPAITSASQRDRPRKPSKRQDGAPRSRGASQKRRTHQLR-DRCSPAGSSRPGSAKAEVARAD 840

Human   823 QNPPHHRTPRNKVTQAKLTGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQ 887
            |:..||.||||||||.||.||:.|.:|.|||||.||.::     |.||...|.|.:.|.||..||
  Rat   841 QSSVHHDTPRNKVTQDKLVGGVSSDVPLSTEELGSGCQK-----LYEDLCASPENNVAHGPRPGQ 900

Human   888 SVNIDLLPVELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDR 952
            ||||.|||||.||.||||||.||||||:||||||||||||||||||||||.|.|:|||||.||.|
  Rat   901 SVNIHLLPVEQRLLIIQRERSRKELFRRKNKAAAVIQRAWRSYQLRKHLSRLLHLKQLGARDVLR 965

Human   953 WRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHEGKIHHPT 1017
            ..|...||||||||||||||||::.:||:..||||||.|..||.:||||:||||||.|||:|||.
  Rat   966 CTQLCAALLLQVWRKELELKFPKSISVSRTSKSPSKGMSAAKSARHSVLRQIYGCSQEGKVHHPI 1030

Human  1018 RSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTK 1064
            ||.|...||.|:||::||.|| |::|||||.||||||.|:|.|||.|
  Rat  1031 RSPKVPPVLHLSSVNSLQSIH-LDSSGRSKKFSYNLQPASQSKNKPK 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INVS	NP_055240.2	ANK 1	13..42		28/28 (100%)
		Ank_2	19..111	CDD:289560	90/91 (99%)
		ANK	42..169	CDD:238125	123/126 (98%)
		ANK repeat	47..78	CDD:293786	30/30 (100%)
		ANK 2	47..76		28/28 (100%)
		ANK repeat	80..146	CDD:293786	63/65 (97%)
		ANK 3	80..110		28/29 (97%)
		Ank_2	85..179	CDD:289560	91/93 (98%)
		ANK 4	113..144		29/30 (97%)
		ANK	143..309	CDD:238125	161/187 (86%)
		ANK repeat	148..179	CDD:293786	29/30 (97%)
		ANK 5	148..177		27/28 (96%)
		ANK repeat	181..218	CDD:293786	35/36 (97%)
		ANK 6	181..213		30/31 (97%)
		Ank_4	185..240	CDD:290365	52/54 (96%)
		ANK repeat	220..252	CDD:293786	30/31 (97%)
		ANK 7	220..250		28/29 (97%)
		Ank_2	225..319	CDD:289560	89/115 (77%)
		ANK 8	254..283		28/28 (100%)
		ANK repeat	256..286	CDD:293786	28/29 (97%)
		ANK 9	288..317		26/50 (52%)
		ANK repeat	288..313	CDD:293786	23/46 (50%)
		Ank_2	293..387	CDD:289560	89/115 (77%)
		ANK	316..443	CDD:238125	123/126 (98%)
		ANK repeat	321..354	CDD:293786	32/32 (100%)
		ANK 10	321..350		28/28 (100%)
		ANK repeat	356..387	CDD:293786	28/30 (93%)
		ANK 11	356..385		26/28 (93%)
		Ank_2	361..453	CDD:289560	88/91 (97%)
		ANK	384..509	CDD:238125	123/124 (99%)
		ANK repeat	389..420	CDD:293786	29/30 (97%)
		ANK 12	389..418		27/28 (96%)
		ANK repeat	422..453	CDD:293786	30/30 (100%)
		ANK 13	422..451		28/28 (100%)
		Ank_2	427..517	CDD:289560	89/89 (100%)
		ANK repeat	455..486	CDD:293786	30/30 (100%)
		ANK 14	455..484		28/28 (100%)
		ANK 15	488..517		28/28 (100%)
		ANK repeat	488..516	CDD:293786	27/27 (100%)
		D-box 1	490..498		7/7 (100%)
		ANK repeat	521..548	CDD:293786	26/26 (100%)
		ANK 16	523..553		29/29 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..833		136/244 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..886		16/38 (42%)
		D-box 2	909..917		6/7 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..999		11/22 (50%)
Invs	XP_038965783.1	Ank_5	33..88	CDD:404699	53/54 (98%)
		ANK repeat	47..78	CDD:293786	30/30 (100%)
		PHA02874	<62..>262	CDD:165205	194/199 (97%)
		ANK repeat	80..111	CDD:293786	29/30 (97%)
		ANK repeat	113..146	CDD:293786	31/32 (97%)
		ANK repeat	150..179	CDD:293786	27/28 (96%)
		ANK repeat	181..218	CDD:293786	35/36 (97%)
		ANK repeat	220..252	CDD:293786	30/31 (97%)
		ANKYR	<252..400	CDD:223738	122/147 (83%)
		ANK repeat	254..286	CDD:293786	30/31 (97%)
		ANK repeat	343..376	CDD:293786	32/32 (100%)
		Ank_2	358..>576	CDD:423045	214/217 (99%)
		ANK repeat	378..409	CDD:293786	28/30 (93%)
		ANK repeat	411..442	CDD:293786	29/30 (97%)
		ANK repeat	444..475	CDD:293786	30/30 (100%)
		ANK repeat	477..508	CDD:293786	30/30 (100%)
		ANK repeat	510..538	CDD:293786	27/27 (100%)
		ANK repeat	543..570	CDD:293786	26/26 (100%)
		PHA03307	634..>899	CDD:223039	141/273 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83679994
Domainoid	1	1.000	356	1.000	Domainoid score	I12519
eggNOG	1	0.900	-	-		E33208_3BITN
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7786
Inparanoid	1	1.050	1603	1.000	Inparanoid score	I2393
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37222
OrthoDB	1	1.010	-	-		D10517at314146
OrthoFinder	1	1.000	-	-		FOG0011574
OrthoInspector	1	1.000	-	-		oto135205
orthoMCL	1	0.900	-	-		OOG6_109706
Panther	1	1.100	-	-	LDO	PTHR24178
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X7227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270