DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HSPB7 and Hsp27

DIOPT Version :9

Sequence 1:	NP_001336611.1	Gene:	HSPB7 / 27129	HGNCID:	5249	Length:	245	Species:	Homo sapiens
Sequence 2:	NP_001287001.1	Gene:	Hsp27 / 39078	FlyBaseID:	FBgn0001226	Length:	213	Species:	Drosophila melanogaster

Alignment Length:	210	Identity:	49/210 - (23%)
Similarity:	72/210 - (34%)	Gaps:	66/210 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    47 WGHL---DWVWAHVSRSSQRGLPGGGGIGA-DLGRKGRIWRGQQRPLTATWAEQRAWPPLRMAST 107
            ||||   |:               |.|:.| ||....|                     |.:.:|
  Fly    21 WGHLLEDDF---------------GFGVHAHDLFHPRR---------------------LLLPNT 49

Human   108 LAQGKDPPMEKALSMFSDDFGSFMRPHSEPLAFPARPGGAGN--IKTLG-DAYEFAVDVRDFSPE 169
            |..|:            ..:..:.|.|........|..|..|  :..:| |.::..:||..|.|.
  Fly    50 LGLGR------------RRYSPYERSHGHHNQMSRRASGGPNALLPAVGKDGFQVCMDVSQFKPN 102

Human   170 DIIVTTSNNHIEVRA---EKLAADGTVMNTFAHKCQLPEDVDPTSVTSALREDGSLTIRARRHPH 231
            ::.|...:|.:.|..   |:....|.:...|..|..||:..||..|.|.:..||.||::|...|.
  Fly   103 ELTVKVVDNTVVVEGKHEEREDGHGMIQRHFVRKYTLPKGFDPNEVVSTVSSDGVLTLKAPPPPS 167

Human   232 TE--------HVQQT 238
            .|        .:|||
  Fly   168 KEQAKSERIVQIQQT 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPB7	NP_001336611.1	ACD_HspB7_like	148..228	CDD:107234	25/85 (29%)
Hsp27	NP_001287001.1	metazoan_ACD	86..163	CDD:107247	23/76 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810