DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYTH4 and SPBC211.03c

DIOPT Version :9

Sequence 1:	NP_037517.1	Gene:	CYTH4 / 27128	HGNCID:	9505	Length:	394	Species:	Homo sapiens
Sequence 2:	NP_596613.1	Gene:	SPBC211.03c / 2540746	PomBaseID:	SPBC211.03c	Length:	1462	Species:	Schizosaccharomyces pombe

Alignment Length:	281	Identity:	82/281 - (29%)
Similarity:	131/281 - (46%)	Gaps:	42/281 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    37 KDEIADVFAQIDCFESAEESRMAQKEKELCI-GRKKFNMDPAKGIQYFIEHKLL--TPDVQDIAR 98
            ||::|....:            ::|.|.:.| |.:.||..|:.||.:..:|.::  :.:...|..
pombe   535 KDDVAKTLIE------------SKKRKAIIIEGAELFNESPSDGIAFLTQHSIIKQSDNPTCIVE 587

Human    99 FLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRM 163
            |.:....|:|..:|.:|.:..  |..:|.||:...:|....:.:|||..|.|||||||:|.|:|:
pombe   588 FFHSTNRLSKRVLGEFLTKGS--NSHILNAFISAFDFKGKRIDEALRLLLQSFRLPGESQLIERV 650

Human   164 MEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDL 226
            :|.|:..|...||....|.|..:|||:|||||||..||||::.  |...:.|....||:|:|.|.
pombe   651 LETFSHYYMSANPDSMSSKDAAFVLSYSIIMLNTDQHNPNIKSQRRMTLDDFCRNVRGVNDGQDF 715

Human   227 PEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVK---TWKRR--------- 279
            ..:.|..::.:||.....:.|:...:|:..:.      | .||...||   .:||.
pombe   716 DRNFLSEIYKAIKENEIIVAEEHDTELSFLYI------W-SKLQQSVKITEPFKRSSSNVHDKIV 773

Human   280 ----WFILTDNCLYYFEFTTD 296
                |..:....:|.|...|:
pombe   774 FLEVWKSIMAALIYVFSTATE 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYTH4	NP_037517.1	Sec7	61..243	CDD:279680	66/186 (35%)
		PH_GRP1-like	258..376	CDD:269954	11/55 (20%)
		PH	262..374	CDD:278594	11/51 (22%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..275		4/9 (44%)
		C-terminal autoinhibitory region. /evidence=ECO:0000250	386..394
SPBC211.03c	NP_596613.1	Sec7_N	287..475	CDD:289549
		COG5307	289..1303	CDD:227623	82/281 (29%)
		Sec7	548..732	CDD:279680	65/185 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910