Protein Alignment DKK2 and drpr

DIOPT Version :10

• Sequence 1: NP_055236.1
• Gene: DKK2 / 27123
• HGNCID: 2892
• Length: 259
• Species: Homo sapiens
• Sequence 2: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Alignment Length: 266
• Identity: 61/266 - (22%)
• Similarity: 83/266 - (31%)
• Gaps: 103/266 - (38%)

Human    67 KKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACM--------VCRRK----------KKRC--- 110
            |.|....|..||.:|.:|:       |..|  |||        ||..|          ::.|
  Fly   222 KHGAQCQQDCPCQNDGKCQ-------PETG--ACMCNPGWTGDVCANKCPVGSYGPGCQESCECY 277

Human   111 ------HRDGMC-CP---------------------STRCN----------NGICI--------P 129
                  |..|.| ||                     |..|:          ||.||        .
  Fly   278 KGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPGWTGAK 342

Human   130 VTESILTPHIPALDGTR-------HRDRNHGHYSN--HDLGWQN--LGRPHTKMSHIKGHEGDPC 183
            ..|.|...:...||..|       |.|..|....|  ..:||.:  ..||.|.:.:     |..|
  Fly   343 CAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRY-----GPNC 402

Human   184 LRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKV------- 241
            ..:.:|..|..|:....|.:|.|. .:|..|.:..:.|:.|.:...||||..|..|:.
  Fly   403 ELTCNCKNGAKCSPVNGTCLCAPG-WRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLC 466

Human   242 ---WKD 244
               ||:
  Fly   467 TAGWKN 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DKK2	NP_055236.1	Dkk2_Cys1	74..128	CDD:438009	23/112 (21%)
		DKK-type Cys-1	78..127		21/107 (20%)
		Dkk2_Cys2	175..258	CDD:437999	20/80 (25%)
		DKK-type Cys-2	183..256		19/72 (26%)
drpr	NP_001261276.1	EMI	26..92	CDD:462204
		EGF_CA	274..319	CDD:473889	8/44 (18%)
		gliding_CglD	<451..579	CDD:468178	5/22 (23%)
		DSL	567..609	CDD:473190