DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DKK2 and drpr

DIOPT Version :9

Sequence 1:	NP_055236.1	Gene:	DKK2 / 27123	HGNCID:	2892	Length:	259	Species:	Homo sapiens
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	61/266 - (22%)
Similarity:	83/266 - (31%)	Gaps:	103/266 - (38%)

- Green bases have known domain annotations that are detailed below.

Human    67 KKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACM--------VCRRK----------KKRC--- 110
            |.|....|..||.:|.:|:       |..|  |||        ||..|          ::.|
  Fly   222 KHGAQCQQDCPCQNDGKCQ-------PETG--ACMCNPGWTGDVCANKCPVGSYGPGCQESCECY 277

Human   111 ------HRDGMC-CP---------------------STRCN----------NGICI--------P 129
                  |..|.| ||                     |..|:          ||.||        .
  Fly   278 KGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPGWTGAK 342

Human   130 VTESILTPHIPALDGTR-------HRDRNHGHYSN--HDLGWQN--LGRPHTKMSHIKGHEGDPC 183
            ..|.|...:...||..|       |.|..|....|  ..:||.:  ..||.|.:.:     |..|
  Fly   343 CAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRY-----GPNC 402

Human   184 LRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKV------- 241
            ..:.:|..|..|:....|.:|.|. .:|..|.:..:.|:.|.:...||||..|..|:.
  Fly   403 ELTCNCKNGAKCSPVNGTCLCAPG-WRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLC 466

Human   242 ---WKD 244
               ||:
  Fly   467 TAGWKN 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DKK2	NP_055236.1	Dickkopf_N	78..128	CDD:282549	21/108 (19%)
		DKK-type Cys-1	78..127		21/107 (20%)
		DKK-type Cys-2	183..256		19/72 (26%)
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	8/44 (18%)
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900