DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB11 and CG31365

DIOPT Version :9

Sequence 1:	NP_055230.2	Gene:	ZBTB11 / 27107	HGNCID:	16740	Length:	1053	Species:	Homo sapiens
Sequence 2:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	156/736 - (21%)
Similarity:	251/736 - (34%)	Gaps:	227/736 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   151 ESEDDLSNFTSSPTTASKPAKKKPVSKHELVFVDTKGVVKRSSPKH-CQAVLKQLNEQRLSNQFC 214
            |.:|..:.|....|..|     .||.....|.:|.|..  .:.||. ||....||.:..|..|.|
  Fly    20 EHQDAYAIFDEDDTQLS-----IPVRLMACVALDAKAT--DTLPKRICQECRYQLEKSFLFRQRC 77

Human   215 DVTLLIEGEEYKAHKSV----LSANSEYFR---DLFIEKGAVSSHEAVVDLSGFCKASFLPLLEF 272
                  :..|.|..|.:    |...|..|.   |.:.|.                        |.
  Fly    78 ------QWAEKKLRKHIRLLGLGKRSRVFSKDPDDYDED------------------------EL 112

Human   273 AYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEV-----QTVASTQD 332
            .:...::|                    :|:.:.|.||.:||....:|:.:.     :.|.|..:
  Fly   113 EFEDSIAF--------------------IEVQDKVRKLEDEKWREDFKEEQAAEMHKRLVKSRLE 157

Human   333 LRVQNGGTAPPVASSEGTTTSLPTELGDCEIVLLVNGELPEAEQN-------------------- 377
            ||.:             .||.|..||.: |:...|..||.|..::
  Fly   158 LRAK-------------LTTELRKELAE-EVRSEVRKELAEEVRSQVRDDLRNEVSEDIRKEQLA 208

Human   378 ---GEV----------------GRQPE--PQVSSEAESALSSVGCIADSHPEMESVDL------- 414
               ||:                |.:||  |||..:|..:.|....:....|.:...:|
  Fly   209 MLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKALPKRRPSLVDANLKATEARK 273

Human   415 ITKNNQTELETSNNRENNTVSNIHPKLSKENVISSSPED----SGMGNDI--------------S 461
            ..|..:..|..:.:..||:..||......|.|.:.|.||    :.:|:|:              |
  Fly   274 DAKEEEFILGCNTDPANNSDVNIDGLELDEEVPAESGEDFREINMVGSDVVHTDNGEIYIINSAS 338

Human   462 AEDICAEDIPKHRQKVDQPLKDQENLVASTAKTDFGPDDDTYRSRLRQRSVNEGAYIRLHKGMEK 526
            :||...:..|:.         ||:|.:.|                   .::.|...|:...
  Fly   339 SEDQNQDSTPEF---------DQDNGITS-------------------YNIKEDGEIQFSG---- 371

Human   527 KLQKRKAVPKSAVQQVAQKLVQRGKK---------MKQPKRDAKENTEEASHKCGECGMVFQRRY 582
              :|.:.:....|..:.:::.|..:.         :::.:.|..|.|.....:..|  :||::..
  Fly   372 --EKPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSE--LVFKQES 432

Human   583 ALIMHKLKH--ERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASGTSSEKG 645
            :....|...  :..:.::|.||...|.....|..|...|.:                 |..|.||
  Fly   433 SCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIK-----------------GLKSGKG 480

Human   646 RTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCE 710
            .|.:   |..|...|....||:.||:.|||:||..|..|..:|..:..||.|...|...|:.||.
  Fly   481 GTLK---CPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCP 542

Human   711 LCVKSFVTKRSLQEHMS-IHTGESK-YLCSVCGKSFHRGSGLSKHFKKHQPKPEVRG--YHCTQC 771
            .|...|..|.:||:|:. :|.|.|: :.|.:|.:||:..||||:|...|      .|  :.|.||
  Fly   543 QCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTH------AGVMFSCKQC 601

Human   772 EKSFFEARDLRQHMNKHLGVK 792
            .:.|.:...:::|:.....||
  Fly   602 GRQFNDRSAVQRHVTTMHKVK 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB11	NP_055230.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..173		5/21 (24%)
		BTB	204..305	CDD:279045	15/107 (14%)
		BTB	215..306	CDD:197585	11/97 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..566		4/28 (14%)
		C2H2 Zn finger	571..591	CDD:275368	4/19 (21%)
		C2H2 Zn finger	599..619	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643		2/23 (9%)
		C2H2 Zn finger	653..673	CDD:275368	7/19 (37%)
		zf-H2C2_2	665..690	CDD:290200	12/24 (50%)
		C2H2 Zn finger	681..701	CDD:275368	6/19 (32%)
		C2H2 Zn finger	709..729	CDD:275368	7/20 (35%)
		zf-H2C2_2	721..746	CDD:290200	10/26 (38%)
		C2H2 Zn finger	737..757	CDD:275368	9/19 (47%)
		C2H2 Zn finger	768..788	CDD:275368	5/19 (26%)
		zf-H2C2_2	780..804	CDD:290200	3/13 (23%)
		C2H2 Zn finger	796..816	CDD:275368
		C2H2 Zn finger	860..880	CDD:275368
		C2H2 Zn finger	888..908	CDD:275368
		zf-H2C2_2	900..923	CDD:290200
		C2H2 Zn finger	916..937	CDD:275368
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	21/78 (27%)
		vATP-synt_E	109..>244	CDD:304907	32/192 (17%)
		RRF	<161..222	CDD:294170	12/74 (16%)
		zf-C2H2_8	454..530	CDD:292531	27/95 (28%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	12/24 (50%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	571..591	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..617	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000