Protein Alignment EIF2AK1 and PEK

DIOPT Version :10

• Sequence 1: NP_055228.2
• Gene: EIF2AK1 / 27102
• HGNCID: 24921
• Length: 630
• Species: Homo sapiens
• Sequence 2: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Alignment Length: 552
• Identity: 171/552 - (30%)
• Similarity: 254/552 - (46%)
• Gaps: 121/552 - (21%)

Human   157 EAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILI--KGATKTVCMKVLREVKVLA 219
            |..|||:.::||.:..||:||:|.|::.:||||...||||:|.:  |.:::   .:||||.:.||
  Fly   632 EHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSR---QRVLREARTLA 693

Human   220 GLQHPNIVGYHTAWIEHVHV-IQPRADR----------AAIELP---SLEVLSDQ-EEDREQ--- 266
            ..:|.|||.|..:|.|.... .|...||          ..||.|   ::..|::| :|.|:|
  Fly   694 SCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKEKRQQQLL 758

Human   267 -----------C----------GVKN-------DESSSSSIIF----------AEPTPEKEKRFG 293
                       |          .:||       ||...|.|.|          ||...:.:..:
  Fly   759 SWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDY- 822

Human   294 ESDTENQNN--------------------KSVKYTTNLVIRESGELESTLELQENGLAGLSASSI 338
            |.|.|.|.:                    |::.|:.:.::..|.::|| :..:.:|....:..:.
  Fly   823 EEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIES-VRPKSSGSDDANDDNK 886

Human   339 VEQQ---LPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLC-ELSLWDWIVERN 399
            ..::   |.|.:|.:..::.:....||...:|  |.......:.|:|||||| :.||.||:
  Fly   887 ARRKPLTLALAQNHNNNQNGSQPTPSSATILN--GTVAKPSKVYLYIQMQLCRKESLRDWL---- 945

Human   400 KRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGL 464
               |:...|:...::     ..||.::|:.|.|:|..|::||||||.|||. ..|.|:|||||||
  Fly   946 ---RDNRSETRAAHI-----GDIFHQIVDAVDYVHLKGLIHRDLKPSNIFF-SQDGQIKIGDFGL 1001

Human   465 ACTDILQKNTDWTNRNGK--------RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLL 521
            . ||:    .|..|...|        ....||.:|||.||.|||||.|..||.|.|:||||::..
  Fly  1002 V-TDM----ADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFF 1061

Human   522 ELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 586
            ||...|.|||||.:.|..||.||.|:......|.|...:|.:......|||...| |:|:|
  Fly  1062 ELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQ-LKSQL---- 1121

Human   587 GNVNLTLQMKIIEQEKEIAELKKQLNLLSQDK 618
            .|: |.|...:.|.:.|.|||.::...||:.:
  Fly  1122 RNI-LQLPHLLSEGQSEQAELAERARRLSRSR 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF2AK1	NP_055228.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		SIFI-degron. /evidence=ECO:0000269|PubMed:38297121	85..104
		STKc_EIF2AK1_HRI	160..581	CDD:270951	158/510 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..301		17/83 (20%)
		HRM 1	410..415		0/4 (0%)
		HRM 2	552..557		1/4 (25%)
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		Protein Kinases, catalytic domain	635..1113	CDD:473864	155/502 (31%)