DRSC/TRiP Functional Genomics Resources

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Protein Alignment EIF2AK1 and Wee1

DIOPT Version :10

Sequence 1:NP_055228.2 Gene:EIF2AK1 / 27102 HGNCID:24921 Length:630 Species:Homo sapiens
Sequence 2:NP_477035.1 Gene:Wee1 / 33965 FlyBaseID:FBgn0011737 Length:609 Species:Drosophila melanogaster


Alignment Length:609 Identity:116/609 - (19%)
Similarity:186/609 - (30%) Gaps:286/609 - (46%)


- Green bases have known domain annotations that are detailed below.


Human   107 FTCSDEFSSLRLHHNRAITH------------LMRSAKERVR--------------------QDP 139
            |..|:...||.||:.:..|.            ||...|:|.|                    .|.
  Fly   137 FRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRTQFGRENLNLNVNAMQKYLLSDA 201

Human   140 CED---------ISRIQKIRSREVAL-EAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYA 194
            |:|         :..|.:...:.:|| :...||:..||.::.::|.|.:|.|::..|:|||..||
  Fly   202 CDDDVTEEAGDSMREIHQQAPKRLALHDTNISRFKREFMQVNVIGVGEFGVVFQCVNRLDGCIYA 266

Human   195 IKKILIKGATKTVCMKVLREVKVLAGL-QHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLS 258
            |||.....|..:...:.|.||...|.| :|.|:|.|::||.|..|::                  
  Fly   267 IKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHML------------------ 313

Human   259 DQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTL 323
                      ::|:                                        ..:.|.|.:.:
  Fly   314 ----------IQNE----------------------------------------FCDGGSLHARI 328

Human   324 ELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCE 388
            :                        .|.                 ||:.|.:..|| |:      
  Fly   329 Q------------------------DHC-----------------LGEAELKIVLM-HV------ 345

Human   389 LSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIF---- 449
                                                  :||:.|||:..:||.||||.|||    
  Fly   346 --------------------------------------IEGLRYIHSNDLVHMDLKPENIFSTMN 372

Human   450 ------LHGPDQQV----------------------KIGDFGLACTDILQKNTDWTNRNGKRTPT 486
                  :....||.                      ||||.|                       
  Fly   373 PNAHKLVEVQPQQTKDDDGMDSVYEELRHSENLVTYKIGDLG----------------------- 414

Human   487 HTSRV-------GTCLYASPEQLEGSEYD--AKSDMYSLGVVLLEL-----FQPFGTEMERAEVL 537
            |.:.|       |.|.|. |:::...:|.  .|:|::|||:.|.|.     ....|.|..     
  Fly   415 HVTSVKEPYVEEGDCRYL-PKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWH----- 473

Human   538 TGLRTGQLP--ESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELF---QNSGNVNLTLQMKI 597
             .||.|::|  .||.:..   .:.|..:......:||::..:....:.   .:...:.|.|::.:
  Fly   474 -NLRDGKVPILPSLSRDF---NELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKSKLQLGLELTV 534

Human   598 IEQEKEI-----AELKKQLNLLSQ 616
            .:::.||     .|.|||:.||.|
  Fly   535 EKRKNEILMNKLREAKKQIKLLEQ 558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EIF2AK1NP_055228.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
SIFI-degron. /evidence=ECO:0000269|PubMed:38297121 85..104
STKc_EIF2AK1_HRI 160..581 CDD:270951 87/469 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..301 1/41 (2%)
HRM 1 410..415 0/4 (0%)
HRM 2 552..557 0/4 (0%)
Wee1NP_477035.1 PTKc_Wee1 238..516 CDD:270953 85/464 (18%)
Blue background indicates that the domain is not in the aligned region.

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