Protein Alignment GK and GUT1

DIOPT Version :10

• Sequence 1: XP_011543793.1
• Gene: GK / 2710
• HGNCID: 4289
• Length: 587
• Species: Homo sapiens
• Sequence 2: NP_011831.1
• Gene: GUT1 / 856353
• SGDID: S000001024
• Length: 709
• Species: Saccharomyces cerevisiae
• Alignment Length: 686
• Identity: 242/686 - (35%)
• Similarity: 339/686 - (49%)
• Gaps: 186/686 - (27%)

Human    11 PLVGAVDQGTSSTRFLVFNSKTAELLSHHQVE-------------------------------IK 44
            ||:.::|.||:|:|.::|| :..:.:|.||:|                               ||
Yeast    47 PLIASIDVGTTSSRCILFN-RWGQDVSKHQIEYSTSASKGKIGVSGLRRPSTAPARETPNAGDIK 110

Human    45 --------------QE--------------------FPREGWVEQDPKEILHSVYECIEKTCEKL 75
                          ||                    ||:.||||..|:::|.:|.:|:..:...|
Yeast   111 TSGKPIFSAEGYAIQETKFLKIEELDLDFHNEPTLKFPKPGWVECHPQKLLVNVVQCLASSLLSL 175

Human    76 GQLNID-ISN------IKAIGVSNQRETTVVWDKITGEPLYNAVAAPVSPGPSVPVAVVPSGSSV 133
            ..:|.: ::|      :..:|::|.||||::|.:.||:|:.|
Yeast   176 QTINSERVANGLPPYKVICMGIANMRETTILWSRRTGKPIVN----------------------- 217

Human   134 PAPGTSSVWLDLRTQSTVE------SLSKRIPGNNNFVKSKTGLP-LSTYFSAVKLRWLLDNVRK 191
                ...||.|.||...|.      |:.:::.     ::.||||| ||||||..||||.|||...
Yeast   218 ----YGIVWNDTRTIKIVRDKWQNTSVDRQLQ-----LRQKTGLPLLSTYFSCSKLRWFLDNEPL 273

Human   192 VQKAVEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPME 256
            ..||.||...:|||:|:|||:.||   ......:||||||||...|:.:|::|.:|.||:||...
Yeast   274 CTKAYEENDLMFGTVDTWLIYQLT---KQKAFVSDVTNASRTGFMNLSTLKYDNELLEFWGIDKN 335

Human   257 I--LPNVRSSSEIYG-------LMKISHSVKAGAL-----EGVPISGCLGDQSAALVGQMCFQIG 307
            :  :|.:.|||:.||       :|:..|......|     ..:||.||||||||::|||:.::.|
Yeast   336 LIHMPEIVSSSQYYGDFGIPDWIMEKLHDSPKTVLRDLVKRNLPIQGCLGDQSASMVGQLAYKPG 400

Human   308 QAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAY------KLGRDKP----VYYALEGSVAIAGAV 362
            .||.|||||||||.|||.|.:.|.||.|||:|:      :.|..||    .::|||||||:||||
Yeast   401 AAKCTYGTGCFLLYNTGTKKLISQHGALTTLAFWFPHLQEYGGQKPELSKPHFALEGSVAVAGAV 465

Human   363 IRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIA 427
            ::||||||.:|..||::..:|..|..|.|..||||||||:||||:|.||..|.|::|||...|||
Yeast   466 VQWLRDNLRLIDKSEDVGPIASTVPDSGGVVFVPAFSGLFAPYWDPDARATIMGMSQFTTASHIA 530

Human   428 FAALEAVCFQTREILDAMNRDC--------------------GIPLSHLQVDGGMTSNKILMQLQ 472
            .||:|.||||.|.||.||:.|.                    ..|||.|.|||||:.:..:||:|
Yeast   531 RAAVEGVCFQARAILKAMSSDAFGEGSKDRDFLEEISDVTYEKSPLSVLAVDGGMSRSNEVMQIQ 595

Human   473 ADIL--YIPVVKPSMPETTALGAAMAAGAA-------------EGVGVW----------SLEPED 512
            ||||  .:.|.:....|.||||||:||..|             ..|..|          .:.||
Yeast   596 ADILGPCVKVRRSPTAECTALGAAIAANMAFKDVNERPLWKDLHDVKKWVFYNGMEKNEQISPE- 659

Human   513 LSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWV 548
             :...::.|..:.:..|....:..|:.||.:|.||:
Yeast   660 -AHPNLKIFRSESDDAERRKHWKYWEVAVERSKGWL 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GK	XP_011543793.1	ASKHA_NBD_FGGY_GK1-3-like	11..544	CDD:466802	239/680 (35%)
GUT1	NP_011831.1	ASKHA_NBD_FGGY_GK1-3-like	47..690	CDD:466802	239/680 (35%)