Protein Alignment GK and Gk1

DIOPT Version :9

• Sequence 1: XP_011543793.1
• Gene: GK / 2710
• HGNCID: 4289
• Length: 587
• Species: Homo sapiens
• Sequence 2: NP_524655.1
• Gene: Gk1 / 43913
• FlyBaseID: FBgn0025592
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 281/556 - (50%)
• Similarity: 367/556 - (66%)
• Gaps: 41/556 - (7%)

Human    10 GPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEK 74
            ||.|||:|:||:|.||::|.:.|.|::..||:|::..|.:|||.||||..|:::|.|||...|:|
  Fly    17 GPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACKK 81

Human    75 LGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVAAPVSPGPSVPVAVVPSGSSVPAPGTS 139
            |..:...:..|..||::||||:|||||:.:|:||.||:
  Fly    82 LVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAI--------------------------- 119

Human   140 SVWLDLRTQSTVESLSKRIPGNN---NFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRA 201
             :|||.||.||||.|.:.||.|.   |:::...|||||.|||.||||||.|||..|.:|:|:..|
  Fly   120 -IWLDNRTTSTVEELLETIPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTA 183

Human   202 LFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSE 266
            :|||||:||:::||||.:.|||.|||||||||||.||.:|:||..|.:|||:|..|||.:.||||
  Fly   184 MFGTIDTWLMYNLTGGKDCGVHKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSE 248

Human   267 IYGLMKISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSD 331
            .||      |:..|.|:|:.|:..||||.||||||.|...||||.|||||||||.|||...|.|.
  Fly   249 FYG------SIAQGVLQGIGITSVLGDQQAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHST 307

Human   332 HGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVP 396
            |||||||.|:|||....:|||||||:||||...|||||:.:|:.|.:||.:|..|..|...||||
  Fly   308 HGLLTTVGYQLGRKAVPFYALEGSVSIAGAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVP 372

Human   397 AFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGG 461
            ||:|||||||...|||:||||::.|...||..|.|||||||.|:|||:|::||.|||:.|.||||
  Fly   373 AFNGLYAPYWNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGG 437

Human   462 MTSNKILMQLQADILYIPVVKPSMPETTALGAAMAA-GAAEGVGVWSLEPEDLSAVTMERFEPQI 525
            ||.|.:.:|||:|::.|.|::..:.||||||||||| .|.|  ..:.:|.....:...|..:|.|
  Fly   438 MTVNNLFLQLQSDLVGIQVLRAKIAETTALGAAMAAYKAVE--NRYQMEAPLSKSGPREAIKPSI 500

Human   526 NAEESEIRYSTWKKAVMKSMGWVTTQSPESGDPSIF 561
            :|.:..:||..||.|:.:|:.|.|:..|: |:...|
  Fly   501 SATDRNLRYQKWKMAIDRSLNWETSTLPQ-GEREAF 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GK	XP_011543793.1	FGGY_GK1-3_metazoa	11..547	CDD:212664	275/539 (51%)
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	275/539 (51%)
		FGGY_GK1-3_metazoa	18..522	CDD:212664	275/539 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143496
Domainoid	1	1.000	290	1.000	Domainoid score	I1557
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	560	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm40769
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2135
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800