DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GK and kat-60L1

DIOPT Version :9

Sequence 1:	XP_011543793.1	Gene:	GK / 2710	HGNCID:	4289	Length:	587	Species:	Homo sapiens
Sequence 2:	NP_001163523.1	Gene:	kat-60L1 / 40715	FlyBaseID:	FBgn0037375	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	221	Identity:	44/221 - (19%)
Similarity:	70/221 - (31%)	Gaps:	89/221 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   342 LGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPA-----FSGL 401
            ||.:..:...||..:......|:| .|..|:    .|.:.:.:|      ...:|.     |.|:
  Fly   370 LGYEVHLVDTLEKDILQRHPCIKW-TDVAGL----NEAKTILQE------AVVLPVIMPEFFKGI 423

Human   402 YAPYWEPSARGII-------------------CGLTQF-------TNKCHIAFAALEAVCFQTRE 440
            ..|:     ||::                   ||.|.|       |:|.......|..:.|:...
  Fly   424 RRPW-----RGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR 483

Human   441 I----------LDAMNRDCGIPLSH-----------LQVDG---GMTSNKILMQLQA-----DI- 475
            .          :||:....|....|           :|:||   .|...|::|.|.|     ||
  Fly   484 FYAPSTIFIDEIDALCASRGSDSEHEASRRFKAELLIQMDGLNASMQEEKVIMVLAATNHPWDID 548

Human   476 ----------LYIPVVKPSMPETTAL 491
                      :|||:  |:....:||
  Fly   549 EAFRRRFEKRIYIPL--PNEGTRSAL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GK	XP_011543793.1	FGGY_GK1-3_metazoa	11..547	CDD:212664	44/221 (20%)
kat-60L1	NP_001163523.1	AAA	426..565	CDD:214640	28/145 (19%)
		AAA	430..563	CDD:278434	24/132 (18%)
		Vps4_C	<638..671	CDD:286426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900